Abstract
BACKGROUND: Pregnant women with chronic myeloid leukemia (CML) can be treated effectively with the tyrosine-kinase inhibitor imatinib, but data regarding fetal and neonatal exposure and safety are limited. CASE: We present a patient with newly diagnosed CML in early pregnancy. Leukapheresis and interferon-a were initiated in the second trimester with limited benefit. Imatinib was subsequently started at 28 weeks of gestation with complete hematologic response within 4 weeks. No significant maternal or neonatal adverse effects were noted, but imatinib and its primary active metabolite concentrated in maternal breast milk and neonatal urine. CONCLUSION: Imatinib is effective for CML in pregnancy, but caution is warranted in light of potentially unrecognized fetal and neonatal effects.
Original language | English (US) |
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Pages (from-to) | 831-834 |
Number of pages | 4 |
Journal | Obstetrics and gynecology |
Volume | 129 |
Issue number | 5 |
DOIs | |
State | Published - 2017 |
ASJC Scopus subject areas
- Obstetrics and Gynecology