Measurement of basilar membrane, reticular lamina, and tectorial membrane vibrations in the intact mouse cochlea

Tianying Ren, Wenxuan He

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

A scanning low-coherence heterodyne interferometer (SLHI) was developed for measuring the microstructural vibration inside the cochlear partition of the intact living cochlea of mice. The sensitivity, frequency response, and dynamic range of the SLHI are comparable with those of a sensitive laser interferometer but the SLHI has a higher spatial resolution along the optical axis. The magnitude and phase of sound-induced vibrations were measured as a function of the focal position along the optical axis. Our data show that the SLHI has sufficient sensitivity, dynamic range, and temporal and spatial resolution to measure sub-nanometer vibrations of the basilar membrane, reticular lamina, and tectorial membrane in the intact living mouse cochlea. High spatial and temporal resolution, compact heterodyne design, and scanning capability make this interferometer an ideal tool to study molecular mechanisms of hearing in normal and genetically-modified mice.

Original languageEnglish (US)
Title of host publicationWhat Fire is in Mine Ears
Subtitle of host publicationProgress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages423-428
Number of pages6
DOIs
StatePublished - 2011
Event11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States
Duration: Jul 16 2011Jul 22 2011

Publication series

NameAIP Conference Proceedings
Volume1403
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
Country/TerritoryUnited States
CityWilliamstown, MA
Period7/16/117/22/11

Keywords

  • basilar membrane
  • cochlea
  • low-coherence interferometer
  • reticular lamina
  • tectorial membrane

ASJC Scopus subject areas

  • General Physics and Astronomy

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