Mechanism of the Sex Difference in Endothelial Dysfunction after Stroke

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35 Scopus citations


Stroke, the number four cause of death in the USA, is a greatly debilitating event resulting from insufficient blood supply to the brain (cerebral ischemia). Endothelial dysfunction, primarily characterized by dampened endothelial-dependent vasodilation, is a major contributor to the development and outcome of stroke. This review discusses the role of soluble epoxide hydrolase, an enzyme responsible for the degradation of vasoprotective epoxyeicosatrienoic acids, in the context of the cerebral vasculature and its contribution to the sexual dimorphic nature of stroke.

Original languageEnglish (US)
Pages (from-to)381-389
Number of pages9
JournalTranslational Stroke Research
Issue number4
StatePublished - Aug 2013


  • Brain
  • EET
  • Endothelia
  • Ischemia
  • Sexual dimorphism
  • sEH

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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