Mechanisms of Bone Destruction in Myeloma

Rebecca Silbermann, G. David Roodman

Research output: Chapter in Book/Report/Conference proceedingChapter


Multiple myeloma (MM) is a plasma cell malignancy characterized by monoclonal paraprotein production. It is the second most common hematologic malignancy and has the highest incidence of bone involvement amongst malignant diseases. Up to 90% of patients with MM have evidence of osteolysis in the form of generalized osteopenia or discrete lytic lesions. Skeletal lesions in MM are distinct from bone involvement in other malignancies and are characterized by generalized increased osteoclast activity and suppressed osteoblast function with decreased new bone formation. This chapter will review the pathophysiology of myeloma bone disease and discuss current treatment strategies and novel targets for management of myeloma bone disease.

Original languageEnglish (US)
Title of host publicationOsteoporosis
Subtitle of host publicationFourth Edition
PublisherElsevier Inc.
Number of pages14
ISBN (Print)9780124158535
StatePublished - Jun 2013
Externally publishedYes


  • Bisphosphonate
  • Bone destruction
  • Multiple myeloma (MM)
  • Nuclear factor-kappaB/receptor activator
  • OBL suppression

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)


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