Abstract
Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I-restricted pathway of antigen presentation, suggesting that impairment of the cytotoxic T lymphocyte response is necessary for the maintenance of this lifestyle. The diverse molecular mechanisms that have so far been discovered employed by Epstein-Barr virus, herpes simplex viruses, and human and murine cytomegaloviruses are described in this review.
Original language | English (US) |
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Pages (from-to) | 523-526 |
Number of pages | 4 |
Journal | Immunology and Cell Biology |
Volume | 74 |
Issue number | 6 |
DOIs | |
State | Published - 1996 |
Keywords
- Epstein-Barr virus
- MHC class I
- antigen presentation
- cytomegalovirus
- cytotoxic T lymphocyte
- herpes simplexvirus
- herpesvirus
- latency
- natural killer cell
- transporter associated with antigen processing
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Cell Biology