Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes

Sanjiv Kaul; Carmen Methner; Zhiping Cao; Anusha Mishra

doi:10.1016/j.jacbts.2022.06.008

Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes

Sanjiv Kaul, Carmen Methner, Zhiping Cao, Anusha Mishra

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at altering pericyte function in myocardial ischemia and infarction.

Original language	English (US)
Pages (from-to)	204-220
Number of pages	17
Journal	JACC: Basic to Translational Science
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/j.jacbts.2022.06.008
State	Published - Feb 2023

Keywords

acute myocardial infarction
blood flow
necrosis
no reflow
pericytes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.jacbts.2022.06.008

Cite this

@article{c48e2a5d8abc47e4b7ae1c17d6425b4d,

title = "Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes",

abstract = "Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at altering pericyte function in myocardial ischemia and infarction.",

keywords = "acute myocardial infarction, blood flow, necrosis, no reflow, pericytes",

author = "Sanjiv Kaul and Carmen Methner and Zhiping Cao and Anusha Mishra",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = feb,

doi = "10.1016/j.jacbts.2022.06.008",

language = "English (US)",

volume = "8",

pages = "204--220",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction

T2 - Potential Role of Pericytes

AU - Kaul, Sanjiv

AU - Methner, Carmen

AU - Cao, Zhiping

AU - Mishra, Anusha

PY - 2023/2

Y1 - 2023/2

N2 - Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at altering pericyte function in myocardial ischemia and infarction.

AB - Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at altering pericyte function in myocardial ischemia and infarction.

KW - acute myocardial infarction

KW - blood flow

KW - necrosis

KW - no reflow

KW - pericytes

UR - http://www.scopus.com/inward/record.url?scp=85146797212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85146797212&partnerID=8YFLogxK

U2 - 10.1016/j.jacbts.2022.06.008

DO - 10.1016/j.jacbts.2022.06.008

M3 - Review article

AN - SCOPUS:85146797212

SN - 2452-302X

VL - 8

SP - 204

EP - 220

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 2

ER -

Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this