Membrane-permeant 3-OH-phosphorylated phosphoinositide derivatives

Carlo Dinkel; Mark Moody; Alexis Traynor-Kaplan; Carsten Schultz

doi:10.1002/1521-3773(20010817)40:16<3004::AID-ANIE3004>3.0.CO;2-O

Membrane-permeant 3-OH-phosphorylated phosphoinositide derivatives

Carlo Dinkel, Mark Moody, Alexis Traynor-Kaplan, Carsten Schultz

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A crucial role in the regulation of epithelial chloride secretion is played by the phosphoinositide PtdIns(3,4,5)P₃. Membrane-permeant derivatives of this and other naturally occurring phosphoinositides have been synthesized. These derivatives, which can be bioactivated, were used in investigations on nasal epithelia of patients suffering from cystic fibrosis (see general scheme).

Original language	English (US)
Pages (from-to)	3004-3008
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	40
Issue number	16
DOIs	https://doi.org/10.1002/1521-3773(20010817)40:16<3004::AID-ANIE3004>3.0.CO;2-O
State	Published - Aug 17 2001
Externally published	Yes

Keywords

Cyclitols
Cystic fibrosis
Phosphoinositides
Secretion
Signal transduction

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/1521-3773(20010817)40:16<3004::AID-ANIE3004>3.0.CO;2-O

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abstract = "A crucial role in the regulation of epithelial chloride secretion is played by the phosphoinositide PtdIns(3,4,5)P3. Membrane-permeant derivatives of this and other naturally occurring phosphoinositides have been synthesized. These derivatives, which can be bioactivated, were used in investigations on nasal epithelia of patients suffering from cystic fibrosis (see general scheme).",

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AU - Moody, Mark

AU - Traynor-Kaplan, Alexis

AU - Schultz, Carsten

PY - 2001/8/17

Y1 - 2001/8/17

N2 - A crucial role in the regulation of epithelial chloride secretion is played by the phosphoinositide PtdIns(3,4,5)P3. Membrane-permeant derivatives of this and other naturally occurring phosphoinositides have been synthesized. These derivatives, which can be bioactivated, were used in investigations on nasal epithelia of patients suffering from cystic fibrosis (see general scheme).

AB - A crucial role in the regulation of epithelial chloride secretion is played by the phosphoinositide PtdIns(3,4,5)P3. Membrane-permeant derivatives of this and other naturally occurring phosphoinositides have been synthesized. These derivatives, which can be bioactivated, were used in investigations on nasal epithelia of patients suffering from cystic fibrosis (see general scheme).

KW - Cyclitols

KW - Cystic fibrosis

KW - Phosphoinositides

KW - Secretion

KW - Signal transduction

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DO - 10.1002/1521-3773(20010817)40:16<3004::AID-ANIE3004>3.0.CO;2-O

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ER -

Membrane-permeant 3-OH-phosphorylated phosphoinositide derivatives

Abstract

Keywords

ASJC Scopus subject areas

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