Methylphenidate decreases regional cerebral blood flow in normal human subjects

Gene Jack Wang; Nora D. Volkow; Joanna S. Fowler; Richard Ferrieri; David J. Schlyer; David Alexoff; Naomi Pappas; Jeffrey Lieberman; Payton King; Donald Warner; Christopher Wong; Robert J. Hitzemann; Alfred P. Wolf

doi:10.1016/0024-3205(94)00873-6

Methylphenidate decreases regional cerebral blood flow in normal human subjects

Gene Jack Wang
, Nora D. Volkow
, Joanna S. Fowler
, Richard Ferrieri
, David J. Schlyer
, David Alexoff
, Naomi Pappas
, Jeffrey Lieberman
, Payton King
, Donald Warner
, Christopher Wong
, Robert J. Hitzemann
, Alfred P. Wolf

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

To assess the effects of methylphenidate (MP) on cerebral blood flow (CBF), 5 healthy males were studied using ¹⁵O-water and positron emission tomography before and after MP (0.5mg/kg iv). MP significantly decreased whole brain CBF at 5-10 minutes (25±11%) and at 30 minutes (20±10%) after its administration. Decrements in CBF were homogeneous throughout the brain (regional decrements 23-30%) and probably reflect the vasoactive properties of MP. The vasoactive properties of MP should be considered when prescribing this drug chronically and/or when giving it to subjects with cerebrovascular compromise.

Original language	English (US)
Pages (from-to)	PL143-PL146
Journal	Life Sciences
Volume	54
Issue number	9
DOIs	https://doi.org/10.1016/0024-3205(94)00873-6
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics

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10.1016/0024-3205(94)00873-6

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@article{832bddf615d245b6b44cf76786eb398a,

title = "Methylphenidate decreases regional cerebral blood flow in normal human subjects",

abstract = "To assess the effects of methylphenidate (MP) on cerebral blood flow (CBF), 5 healthy males were studied using 15O-water and positron emission tomography before and after MP (0.5mg/kg iv). MP significantly decreased whole brain CBF at 5-10 minutes (25±11\%) and at 30 minutes (20±10\%) after its administration. Decrements in CBF were homogeneous throughout the brain (regional decrements 23-30\%) and probably reflect the vasoactive properties of MP. The vasoactive properties of MP should be considered when prescribing this drug chronically and/or when giving it to subjects with cerebrovascular compromise.",

author = "Wang, \{Gene Jack\} and Volkow, \{Nora D.\} and Fowler, \{Joanna S.\} and Richard Ferrieri and Schlyer, \{David J.\} and David Alexoff and Naomi Pappas and Jeffrey Lieberman and Payton King and Donald Warner and Christopher Wong and Hitzemann, \{Robert J.\} and Wolf, \{Alfred P.\}",

note = "Funding Information: This work was supported by U.S. Department of Energy under contract DE-AC02-76CH00016 and NIH NS 15638. The authors thank C. Barrette, R. Carciello, K. Johannesen, T. Johnson, R. MacGregor, T. Martin, N. Netusil, C. Redvanly, C. Shea for their participation in various aspects of this work.",

year = "1994",

doi = "10.1016/0024-3205(94)00873-6",

language = "English (US)",

volume = "54",

pages = "PL143--PL146",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "9",

}

TY - JOUR

T1 - Methylphenidate decreases regional cerebral blood flow in normal human subjects

AU - Wang, Gene Jack

AU - Volkow, Nora D.

AU - Fowler, Joanna S.

AU - Ferrieri, Richard

AU - Schlyer, David J.

AU - Alexoff, David

AU - Pappas, Naomi

AU - Lieberman, Jeffrey

AU - King, Payton

AU - Warner, Donald

AU - Wong, Christopher

AU - Hitzemann, Robert J.

AU - Wolf, Alfred P.

N1 - Funding Information: This work was supported by U.S. Department of Energy under contract DE-AC02-76CH00016 and NIH NS 15638. The authors thank C. Barrette, R. Carciello, K. Johannesen, T. Johnson, R. MacGregor, T. Martin, N. Netusil, C. Redvanly, C. Shea for their participation in various aspects of this work.

PY - 1994

Y1 - 1994

N2 - To assess the effects of methylphenidate (MP) on cerebral blood flow (CBF), 5 healthy males were studied using 15O-water and positron emission tomography before and after MP (0.5mg/kg iv). MP significantly decreased whole brain CBF at 5-10 minutes (25±11%) and at 30 minutes (20±10%) after its administration. Decrements in CBF were homogeneous throughout the brain (regional decrements 23-30%) and probably reflect the vasoactive properties of MP. The vasoactive properties of MP should be considered when prescribing this drug chronically and/or when giving it to subjects with cerebrovascular compromise.

AB - To assess the effects of methylphenidate (MP) on cerebral blood flow (CBF), 5 healthy males were studied using 15O-water and positron emission tomography before and after MP (0.5mg/kg iv). MP significantly decreased whole brain CBF at 5-10 minutes (25±11%) and at 30 minutes (20±10%) after its administration. Decrements in CBF were homogeneous throughout the brain (regional decrements 23-30%) and probably reflect the vasoactive properties of MP. The vasoactive properties of MP should be considered when prescribing this drug chronically and/or when giving it to subjects with cerebrovascular compromise.

UR - https://www.scopus.com/pages/publications/0028222020

UR - https://www.scopus.com/pages/publications/0028222020#tab=citedBy

U2 - 10.1016/0024-3205(94)00873-6

DO - 10.1016/0024-3205(94)00873-6

M3 - Article

C2 - 8114609

AN - SCOPUS:0028222020

SN - 0024-3205

VL - 54

SP - PL143-PL146

JO - Life Sciences

JF - Life Sciences

IS - 9

ER -

Methylphenidate decreases regional cerebral blood flow in normal human subjects

Abstract

ASJC Scopus subject areas

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