Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat: suppression of noxious-evoked activity of nucleus raphe magnus neurons

Mary M. Heinricher; J. Peter Rosenfeld

doi:10.1016/0006-8993(85)91458-1

Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat: suppression of noxious-evoked activity of nucleus raphe magnus neurons

Mary M. Heinricher, J. Peter Rosenfeld

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Microinjection of 1 μg of morphine into nucleus reticularis paragigantocellularis (Pgc) of anesthetized rats depressed both noxious-evoked and spontaneous activity of nociresponsive neurons in the nucleus raphe magnus (NRM). This effect was naloxone-reversible, and was not observed after control injections dorsal to Pgc. The percent change in spontaneous firing was significantly greater than the percent change in pinch-evoked firing. This reduction in NRM neuronal discharge may contribute to the antinociceptive effects produced by microinjection of morphine into Pgc.

Original language	English (US)
Pages (from-to)	388-391
Number of pages	4
Journal	Brain research
Volume	359
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(85)91458-1
State	Published - Dec 16 1985
Externally published	Yes

Keywords

analgesia
microinjection
morphine
nucleus raphe magnus
nucleus reticularis paragigantocellularis
pain

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(85)91458-1

Cite this

@article{de60115623814f35a495eec0339a4b58,

title = "Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat: suppression of noxious-evoked activity of nucleus raphe magnus neurons",

abstract = "Microinjection of 1 μg of morphine into nucleus reticularis paragigantocellularis (Pgc) of anesthetized rats depressed both noxious-evoked and spontaneous activity of nociresponsive neurons in the nucleus raphe magnus (NRM). This effect was naloxone-reversible, and was not observed after control injections dorsal to Pgc. The percent change in spontaneous firing was significantly greater than the percent change in pinch-evoked firing. This reduction in NRM neuronal discharge may contribute to the antinociceptive effects produced by microinjection of morphine into Pgc.",

keywords = "analgesia, microinjection, morphine, nucleus raphe magnus, nucleus reticularis paragigantocellularis, pain",

author = "Heinricher, {Mary M.} and Rosenfeld, {J. Peter}",

year = "1985",

month = dec,

day = "16",

doi = "10.1016/0006-8993(85)91458-1",

language = "English (US)",

volume = "359",

pages = "388--391",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat

T2 - suppression of noxious-evoked activity of nucleus raphe magnus neurons

AU - Heinricher, Mary M.

AU - Rosenfeld, J. Peter

PY - 1985/12/16

Y1 - 1985/12/16

N2 - Microinjection of 1 μg of morphine into nucleus reticularis paragigantocellularis (Pgc) of anesthetized rats depressed both noxious-evoked and spontaneous activity of nociresponsive neurons in the nucleus raphe magnus (NRM). This effect was naloxone-reversible, and was not observed after control injections dorsal to Pgc. The percent change in spontaneous firing was significantly greater than the percent change in pinch-evoked firing. This reduction in NRM neuronal discharge may contribute to the antinociceptive effects produced by microinjection of morphine into Pgc.

AB - Microinjection of 1 μg of morphine into nucleus reticularis paragigantocellularis (Pgc) of anesthetized rats depressed both noxious-evoked and spontaneous activity of nociresponsive neurons in the nucleus raphe magnus (NRM). This effect was naloxone-reversible, and was not observed after control injections dorsal to Pgc. The percent change in spontaneous firing was significantly greater than the percent change in pinch-evoked firing. This reduction in NRM neuronal discharge may contribute to the antinociceptive effects produced by microinjection of morphine into Pgc.

KW - analgesia

KW - microinjection

KW - morphine

KW - nucleus raphe magnus

KW - nucleus reticularis paragigantocellularis

KW - pain

UR - http://www.scopus.com/inward/record.url?scp=0022372788&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022372788&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(85)91458-1

DO - 10.1016/0006-8993(85)91458-1

M3 - Article

C2 - 4075159

AN - SCOPUS:0022372788

SN - 0006-8993

VL - 359

SP - 388

EP - 391

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Microinjection of morphine into nucleus reticularis paragigantocellularis of the rat: suppression of noxious-evoked activity of nucleus raphe magnus neurons

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this