Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission

Don P. Wolf; Shoukhrat Mitalipov

doi:10.1016/j.cmet.2014.06.012

Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission

Don P. Wolf, Shoukhrat Mitalipov

Vaccine and Gene Therapy Institute

Research output: Contribution to journal › Short survey › peer-review

11 Scopus citations

Abstract

Mitochondrial DNA diseases are relatively common, sometimes devastating, and transmitted exclusively through the egg to children of carrier mothers. A study in Cell by Wang et al. (2014) adds the exciting possibility of a new therapy for preventing mitochondrial disease transmission predicated on the use of polar body genomes in mice.

Original language	English (US)
Pages (from-to)	6-8
Number of pages	3
Journal	Cell Metabolism
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2014.06.012
State	Published - Jul 1 2014

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2014.06.012

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title = "Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission",

abstract = "Mitochondrial DNA diseases are relatively common, sometimes devastating, and transmitted exclusively through the egg to children of carrier mothers. A study in Cell by Wang et al. (2014) adds the exciting possibility of a new therapy for preventing mitochondrial disease transmission predicated on the use of polar body genomes in mice.",

author = "Wolf, {Don P.} and Shoukhrat Mitalipov",

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N2 - Mitochondrial DNA diseases are relatively common, sometimes devastating, and transmitted exclusively through the egg to children of carrier mothers. A study in Cell by Wang et al. (2014) adds the exciting possibility of a new therapy for preventing mitochondrial disease transmission predicated on the use of polar body genomes in mice.

AB - Mitochondrial DNA diseases are relatively common, sometimes devastating, and transmitted exclusively through the egg to children of carrier mothers. A study in Cell by Wang et al. (2014) adds the exciting possibility of a new therapy for preventing mitochondrial disease transmission predicated on the use of polar body genomes in mice.

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Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission

Abstract

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