Mitochondrial replacement therapies can circumvent mtDNA-based disease transmission

Don P. Wolf, Shoukhrat Mitalipov

    Research output: Contribution to journalShort surveypeer-review

    10 Scopus citations


    Mitochondrial DNA diseases are relatively common, sometimes devastating, and transmitted exclusively through the egg to children of carrier mothers. A study in Cell by Wang et al. (2014) adds the exciting possibility of a new therapy for preventing mitochondrial disease transmission predicated on the use of polar body genomes in mice.

    Original languageEnglish (US)
    Pages (from-to)6-8
    Number of pages3
    JournalCell Metabolism
    Issue number1
    StatePublished - Jul 1 2014

    ASJC Scopus subject areas

    • Physiology
    • Molecular Biology
    • Cell Biology


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