Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions

Gray Pearson, Fred Robinson, Tara Beers Gibson, Bing E. Xu, Mahesh Karandikar, Kevin Berman, Melanie H. Cobb

Research output: Contribution to journalReview articlepeer-review

3648 Scopus citations


Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2.

Original languageEnglish (US)
Pages (from-to)153-183
Number of pages31
JournalEndocrine reviews
Issue number2
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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