@article{72a817fbce5242e2801705e0724662c8,
title = "Modeling the HIV protease inhibitor adherence-resistance curve by use of empirically derived estimates",
abstract = "The standard view postulates a bell-shaped relationship between adherence to therapy and development of drug-resistant human immunodeficiency virus (HIV), with a resistance peak at a moderate level of adherence. This relationship has not been confirmed empirically. We statistically modeled the relationship between adherence and development of drug resistance, using empirically defined relationships of the rate of viral suppression and drug-resistance-mutation accumulation derived from patients receiving protease-inhibitor-based therapy. We found that the maximal rate of drug resistance occurs at 87% adherence and declines modestly at 100% adherence. Higher levels of viral suppression at 100% adherence (a marker of greater regimen potency) progressively reduce the overall population rate of drug resistance and shift the peak resistance rate to lower levels of adherence.",
author = "Bangsberg, {David R.} and Porco, {Travis C.} and C. Kagay and Charlebois, {Edwin D.} and Deeks, {Steven G.} and David Guzman and Richard Clark and Andrew Moss",
note = "Funding Information: Received 30 June 2003; accepted 24 November 2003; electronically published 9 June 2004. Presented in part: XIth International HIV Drug Resistance Workshop, Seville (abstract 160). Potential conflicts of interest: D.R.B. received grant support and/or speaking honoria from Abbott, Pfizer, and Glaxo-SmithKline. S.G.D. received research support and/or speaking honoria from Trimeris, Agrouron, Glaxo-SmithKline, Bristol-Myers Squibb, and Hoffmann La Roche. Financial support: National Institute of Mental Health grants 54907 and 6301. D.R.B. received additional funding from The Doris Duke Charitable Foundation. a The Epidemiology and Prevention Interventions Center, Positive Health Program, and Center for AIDS Prevention Studies are programs of the University of California–San Francisco AIDS Research Institute. Reprints or correspondence: Dr. David R. Bangsberg, Box 1372, San Francisco General Hospital, UCSF 1001 Potrero Ave., Bldg. 100, Rm. 301, San Francisco, CA 94110 (db@epi-center.ucsf.edu).",
year = "2004",
month = jul,
day = "1",
doi = "10.1086/420790",
language = "English (US)",
volume = "190",
pages = "162--165",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",
}