Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor

Medicine & Life Sciences

• Adenosine Diphosphate 39%
• Amino Acid Substitution 14%
• Amino Acids 45%
• Congenital Hyperinsulinism 20%
• Diazoxide 17%
• Glyburide 15%
• Hydrophobic and Hydrophilic Interactions 14%
• KATP Channels 83%
• Leucine 13%
• Mutation 14%
• Pharmacology 8%
• Phenylalanine 43%
• Pinacidil 19%
• Protein Isoforms 10%
• Protein Transport 14%
• Sequence Deletion 14%
• Sulfonylurea Receptors 100%

Chemical Compounds

• Acid 22%
• Diazoxide 28%
• Hydrophobicity 13%
• Leucine 17%
• Metabolic 13%
• MgADP 72%
• Mutation 41%
• Pharmacological Property 19%
• Phenylalanine 49%
• Pinacidil 29%
• Protein 6%
• Substitution Reaction 10%
• Surface 5%