Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects

S. James Ratnakar; Mark Woods; Angelo J.M. Lubag; Zoltán Kovács; A. Dean Sherry

doi:10.1021/ja076325y

Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects

S. James Ratnakar, Mark Woods, Angelo J.M. Lubag, Zoltán Kovács, A. Dean Sherry

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

The chemical exchange saturation transfer (CEST) efficiency for a series Eu³⁺-based tetraamide complexes bearing p-substituents on a single coordinating pendant arm is highly sensitive to water exchange rates. The CEST effect increases in the order Me < MeO < F_∼ CO₂^tBu < CN_≪ H. These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction.

Original language	English (US)
Pages (from-to)	6-7
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	1
DOIs	https://doi.org/10.1021/ja076325y
State	Published - Jan 9 2008
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja076325y

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abstract = "The chemical exchange saturation transfer (CEST) efficiency for a series Eu3+-based tetraamide complexes bearing p-substituents on a single coordinating pendant arm is highly sensitive to water exchange rates. The CEST effect increases in the order Me < MeO < F∼ CO2tBu < CN≪ H. These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction.",

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AU - Woods, Mark

AU - Lubag, Angelo J.M.

AU - Kovács, Zoltán

AU - Sherry, A. Dean

PY - 2008/1/9

Y1 - 2008/1/9

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AB - The chemical exchange saturation transfer (CEST) efficiency for a series Eu3+-based tetraamide complexes bearing p-substituents on a single coordinating pendant arm is highly sensitive to water exchange rates. The CEST effect increases in the order Me < MeO < F∼ CO2tBu < CN≪ H. These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction.

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Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects

Abstract

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