Molecular diagnosis: Implications for ophthalmology

James T. Rosenbaum; Cailin H. Sibley; Dongseok Choi; Christina A. Harrington; Stephen R. Planck

doi:10.1016/j.preteyeres.2015.11.001

Molecular diagnosis: Implications for ophthalmology

James T. Rosenbaum
, Cailin H. Sibley
, Dongseok Choi
, Christina A. Harrington
, Stephen R. Planck

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labeled precision medicine. Jameson and Longo define precision medicine as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations" (Jameson and Longo, 2015). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.

Original language	English (US)
Pages (from-to)	25-33
Number of pages	9
Journal	Progress in Retinal and Eye Research
Volume	50
DOIs	https://doi.org/10.1016/j.preteyeres.2015.11.001
State	Published - Jan 1 2016

Funding

The authors are grateful for funding support from the National Eye Institute (Grants EY020249 and P30 EY 010572 ), and funding from the Stan and Madelle Rosenfeld Family Trust , the William and Mary Bauman Foundation , and Research to Prevent Blindness , New York. This work would not be possible without the efforts of the Orbital Inflammatory Disease Consortium which includes David J Wilson, Hans Grossniklaus, Roger Dailey, John Ng, Eric Steele Craig Czyz, Jill Foster, David Tse, Chris Alabiad, Sander Dubovy, Prashant Parekh, Gerald Harris, Michael Kazim, Payal Patel, Valerie White, Peter Dolman, Bobby Korn, Don Kikkawa, Deepak Edward, Hind Alkatan, Hailah Al-Hussain, R. Patrick Yeatts, Dinesh Selva D, and Patrick Stauffer.

Funders	Funder number
Stan and Madelle Rosenfeld Family Trust
William and Mary Bauman Foundation
National Eye Institute and Casey Eye Institute	P30 EY 010572, R01EY020249
Research to Prevent Blindness

Keywords

Granulomatosis with polyangiitis
Molecular diagnosis
Nonspecific orbital inflammatory disease
Sarcoidosis
Thyroid eye disease
Transcriptomics

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1016/j.preteyeres.2015.11.001

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title = "Molecular diagnosis: Implications for ophthalmology",

abstract = "The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labeled precision medicine. Jameson and Longo define precision medicine as {"}treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations{"} (Jameson and Longo, 2015). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.",

keywords = "Granulomatosis with polyangiitis, Molecular diagnosis, Nonspecific orbital inflammatory disease, Sarcoidosis, Thyroid eye disease, Transcriptomics",

author = "Rosenbaum, \{James T.\} and Sibley, \{Cailin H.\} and Dongseok Choi and Harrington, \{Christina A.\} and Planck, \{Stephen R.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Published by Elsevier Ltd.",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.preteyeres.2015.11.001",

language = "English (US)",

volume = "50",

pages = "25--33",

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T2 - Implications for ophthalmology

AU - Rosenbaum, James T.

AU - Sibley, Cailin H.

AU - Choi, Dongseok

AU - Harrington, Christina A.

AU - Planck, Stephen R.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labeled precision medicine. Jameson and Longo define precision medicine as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations" (Jameson and Longo, 2015). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.

AB - The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labeled precision medicine. Jameson and Longo define precision medicine as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations" (Jameson and Longo, 2015). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.

KW - Granulomatosis with polyangiitis

KW - Molecular diagnosis

KW - Nonspecific orbital inflammatory disease

KW - Sarcoidosis

KW - Thyroid eye disease

KW - Transcriptomics

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UR - https://www.scopus.com/pages/publications/84955265030#tab=citedBy

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DO - 10.1016/j.preteyeres.2015.11.001

M3 - Review article

C2 - 26608807

AN - SCOPUS:84955265030

SN - 1350-9462

VL - 50

SP - 25

EP - 33

JO - Progress in Retinal and Eye Research

JF - Progress in Retinal and Eye Research

ER -

Molecular diagnosis: Implications for ophthalmology

Abstract

Funding

Keywords

ASJC Scopus subject areas

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