Molecular imaging with targeted contrast ultrasound

Mark Piedra, Achim Allroggen, Jonathan R. Lindner

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Molecular imaging with contrast-enhanced ultrasound uses targeted microbubbles that are retained in diseased tissue. The resonant properties of these microbubbles produce acoustic signals in an ultrasound field. The microbubbles are targeted to diseased tissue by using certain chemical constituents in the microbubble shell or by attaching disease-specific ligands such as antibodies to the microbubble. In this review, we discuss the applications of this technique to pathological states in the cerebrovascular system including atherosclerosis, tumor angiogenesis, ischemia, intravascular thrombus, and inflammation.

Original languageEnglish (US)
Pages (from-to)66-74
Number of pages9
JournalCerebrovascular Diseases
Issue numberSUPPL. 2
StatePublished - Apr 2009
Externally publishedYes


  • Atherosclerosis
  • Contrast-enhanced ultrasound
  • Inflammation
  • Intravascular thrombus
  • Ischemia
  • Molecular imaging
  • Tumor angiogenesis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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