@article{d67cc37311214182bb1dc0adf11e8640,
title = "Molecular Mechanisms of Rhabdomyolysis-Induced Kidney Injury: From Bench to Bedside",
abstract = "Rhabdomyolysis-induced acute kidney injury (RIAKI) occurs following damage to the muscular sarcolemma sheath, resulting in the leakage of myoglobin and other metabolites that cause kidney damage. Currently, the sole recommended clinical treatment for RIAKI is aggressive fluid resuscitation, but other potential therapies, including pretreatments for those at risk for developing RIAKI, are under investigation. This review outlines the mechanisms and clinical significance of RIAKI, investigational treatments and their specific targets, and the status of ongoing research trials.",
keywords = "RIAKI, acute kidney injury, rhabdomyolysis, treatment",
author = "Hebert, {Jessica F.} and Burfeind, {Kevin G.} and Darren Malinoski and Hutchens, {Michael P.}",
note = "Funding Information: The authors have no conflicting financial interests to disclose. JFH is supported by the Oregon Students Learn and Experience Research (OSLER) TL1 grant TL1TR002371. KGB received research support resources provided by the OHSU Department of Anesthesiology & Perioperative Medicine. This work was supported in part by the United States Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development (VA Merit Award #1I01BX004288 to MPH), and the United States Department of Defense (W81XWH2010196 to MPH). This material is also the result of work supported by resources and the use of facilities at the Portland Veterans Affairs Medical Center in Portland, Oregon. The contents do not represent the views of the US Department of Veterans Affairs or the US Government. Publisher Copyright: {\textcopyright} 2022 International Society of Nephrology",
year = "2023",
month = jan,
doi = "10.1016/j.ekir.2022.09.026",
language = "English (US)",
volume = "8",
pages = "17--29",
journal = "Kidney International Reports",
issn = "2468-0249",
publisher = "Elsevier Inc.",
number = "1",
}