Molecular targets of disulfiram action on song maturation in zebra finches

Natalia I. Denisenko-Nehrbass; Claudio V. Mello

doi:10.1016/S0169-328X(01)00002-X

Molecular targets of disulfiram action on song maturation in zebra finches

Natalia I. Denisenko-Nehrbass, Claudio V. Mello

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Disulfiram, an aldehyde dehydrogenase inhibitor, interferes with normal song maturation when applied to brain nucleus HVC of male zebra finches. We present here evidence from Western blots and enzymatic assays showing that known disulfiram targets other than retinaldehyde-specific aldehyde dehydrogenase (zRalDH) are absent in HVC. These findings are consistent with the conclusion that disulfiram disrupts song maturation by interfering with retinoic acid production.

Original language	English (US)
Pages (from-to)	246-250
Number of pages	5
Journal	Molecular Brain Research
Volume	87
Issue number	2
DOIs	https://doi.org/10.1016/S0169-328X(01)00002-X
State	Published - Mar 5 2001

Keywords

Aldehyde dehydrogenase
Birdsong
Retinoic acid
Song control system
Vocal learning

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/S0169-328X(01)00002-X

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title = "Molecular targets of disulfiram action on song maturation in zebra finches",

abstract = "Disulfiram, an aldehyde dehydrogenase inhibitor, interferes with normal song maturation when applied to brain nucleus HVC of male zebra finches. We present here evidence from Western blots and enzymatic assays showing that known disulfiram targets other than retinaldehyde-specific aldehyde dehydrogenase (zRalDH) are absent in HVC. These findings are consistent with the conclusion that disulfiram disrupts song maturation by interfering with retinoic acid production.",

keywords = "Aldehyde dehydrogenase, Birdsong, Retinoic acid, Song control system, Vocal learning",

author = "Denisenko-Nehrbass, {Natalia I.} and Mello, {Claudio V.}",

note = "Funding Information: We would like to thank G. Mueller (USUHS, Bethesda, MD) for the anti-PHM (Ab1761) antibody, the bird keepers at the Rockefeller University Field Research Center in Millbrook, NY, for animal care, and Fernando Nottebohm and Jean-Antoine Girault for their support and encouragement. Supported by an NIDCD grant to C.V.M.",

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T1 - Molecular targets of disulfiram action on song maturation in zebra finches

AU - Denisenko-Nehrbass, Natalia I.

AU - Mello, Claudio V.

N1 - Funding Information: We would like to thank G. Mueller (USUHS, Bethesda, MD) for the anti-PHM (Ab1761) antibody, the bird keepers at the Rockefeller University Field Research Center in Millbrook, NY, for animal care, and Fernando Nottebohm and Jean-Antoine Girault for their support and encouragement. Supported by an NIDCD grant to C.V.M.

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N2 - Disulfiram, an aldehyde dehydrogenase inhibitor, interferes with normal song maturation when applied to brain nucleus HVC of male zebra finches. We present here evidence from Western blots and enzymatic assays showing that known disulfiram targets other than retinaldehyde-specific aldehyde dehydrogenase (zRalDH) are absent in HVC. These findings are consistent with the conclusion that disulfiram disrupts song maturation by interfering with retinoic acid production.

AB - Disulfiram, an aldehyde dehydrogenase inhibitor, interferes with normal song maturation when applied to brain nucleus HVC of male zebra finches. We present here evidence from Western blots and enzymatic assays showing that known disulfiram targets other than retinaldehyde-specific aldehyde dehydrogenase (zRalDH) are absent in HVC. These findings are consistent with the conclusion that disulfiram disrupts song maturation by interfering with retinoic acid production.

KW - Aldehyde dehydrogenase

KW - Birdsong

KW - Retinoic acid

KW - Song control system

KW - Vocal learning

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Molecular targets of disulfiram action on song maturation in zebra finches

Abstract

Keywords

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