Abstract
Background: Otub1 suppresses E2 UbcH5 to stabilize and activate p53. Results: UbcH5 monoubiquitinates Otub1, and monoubiquitination-defective Otub1 mutants fail to inhibit UbcH5 and induce p53. Conclusion: Monoubiquitination is critical for Otub1 to suppress UbcH5 and induce p53. Significance: We report the discovery of a novel molecular mechanism underlying Otub1 suppression of E2 and activation of p53.
Original language | English (US) |
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Pages (from-to) | 5097-5108 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 8 |
DOIs | |
State | Published - Feb 21 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology