Morphine enhances adenosine release from the in vivo rat chemical cortex

John W. Phillis, Zhigen G. Jiang, Brian J. Chelack, Peter H. Wu

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Morphine (1 and 5 mg/kg), administered intravenously, increased the rate of efflux of purines from intact rat cerebral cortises prelabelled with 3H-adenosine. Naloxone antagonized morphine's action. It is suggested that the depressant actions of morphine on transmission in the central nervous system may be related to this enhancement of extracellular levels of adenosine and the adenine nucleotides.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number1
StatePublished - 1980
Externally publishedYes


  • Adenosine release
  • Cerebral cortex
  • Morphine

ASJC Scopus subject areas

  • Pharmacology


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