Abstract
MR1 is a non-classical class I molecule that is highly conserved among mammals. Though discovered in 1995, only recently have MR1 ligands and antigens for MR1-restricted T cells been described. Unlike the traditional class I molecules HLA-A, –B, and –C, little MR1 is on the cell surface. Rather, MR1 resides in discrete intracellular vesicles and the endoplasmic reticulum, and can present non-peptidic small molecules such as those found in the riboflavin biosynthesis pathway. Since mammals do not synthesize riboflavin, MR1 can serve as a sensor of the microbial metabolome and could be key to the early detection of intracellular infection. This review will summarize the current understanding of MR1-dependent antigen presentation.
Original language | English (US) |
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Pages (from-to) | 58-64 |
Number of pages | 7 |
Journal | Seminars in Cell and Developmental Biology |
Volume | 84 |
DOIs | |
State | Published - Dec 2018 |
Keywords
- Antigen presentation
- MR1
- Mucosal associated invariant T cells
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology