Multi-scale and -contrast sensorless adaptive optics optical coherence tomography

Myeong Jin Ju, Destiny Hsu, Ji Hoon Kwon, Daniel J. Wahl, Stefano Bonora, Yifan Jian, Shuichi Makita, Yoshiaki Yasuno, Marinko V. Sarunic

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: The roles of the retinal microvasculature and the retinal pigment epithelium (RPE) in maintaining the health and metabolic activity of the retina lend great clinical value to their high-resolution visualization. Methods: By integrating polarization diversity detection (PDD) into multi-scale and -contrast sensorless adaptive optics optical coherence tomography (MSC-SAO-OCT), we have developed a novel multi-contrast SAO OCT system for imaging pigment in the RPE as well as flow in the retinal capillaries using OCT angiography (OCTA). Aberration correction was performed based on the image quality using transmissive deformable optical elements. Results: MSC-SAO-OCTA imaging was performed at multiple fields-of-view (FOVs) with adjustable numerical aperture (NA). Retinal flow and RPE structural images for in vivo healthy and pathological human posterior eyes were demonstrated to show clinical feasibility of the system. Conclusions: High-resolution imaging of retinal vasculature at both large and small FOVs, as well as characterization of RPE topology and deformation, enables more sophisticated and concise investigation of retinal pathologies for in vivo human imaging. MSC imaging may permit detection and analysis of even subtle deformations in the RPE layer using a single instrument.

Original languageEnglish (US)
Pages (from-to)757-768
Number of pages12
JournalQuantitative Imaging in Medicine and Surgery
Issue number5
StatePublished - 2019


  • Adaptive optics
  • Angiography
  • Ophthalmology
  • Optical coherence tomography (OCT)
  • Polarimetric imaging
  • Retina

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Multi-scale and -contrast sensorless adaptive optics optical coherence tomography'. Together they form a unique fingerprint.

Cite this