@article{f02a33070d944943b8a2c5ecafce2dfb,
title = "Multiple binding sites for bacterial superantigens on soluble class II MHC molecules",
abstract = "We used surface plasmon resonance to study the binding of a set of soluble mouse I-E class II major histocompatibility molecules, each occupied by a different single peptide, to the staphylococcal enterotoxin superantigens, SEA and SEB. The rates of association and dissociation to SEA varied greatly depending on the I-E-bound peptide. By contrast, binding to SEB yielded fast association and dissociation rates, which were relatively peptide independent. The results also indicated nonoverlapping binding sites for SEB and SEA on class II and raised the possibility of enhanced SAg presentation to T cells by cross-linking of cell surface class II.",
author = "Haruo Kozono and David Parker and Janice White and Philippa Marrack and John Kappler",
note = "Funding Information: This work was supported in part by United States Public Health Service grants Al-16765, Al17134, and A122295. We thank Drs. D. McKean (Mayo Clinic, Rochester, Minnesota), D. Mathis (IGBMC, Strasbourg, France), P. Jones (Stanford University, Palo Alto, California) and Lau-rie Glimcher (Harvard School for Public Health, Boston, Massachusetts) for helpful discussions on the location of anti-class II MAb epitopes. We are grateful also to Dr. H. Fischer for preparing the 6H61Y mutant, to Dr. D. Fremont (Columbia Medical School, New York) for help in preparing Figure 7, and to J. Clements and F. Crawford for technical assistance.",
year = "1995",
month = aug,
doi = "10.1016/1074-7613(95)90088-8",
language = "English (US)",
volume = "3",
pages = "187--196",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "2",
}