TY - JOUR
T1 - Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways
AU - Coussens, Lisa
AU - Parker, Peter J.
AU - Rhee, Lucy
AU - Yang-Feng, Teresa L.
AU - Chen, Ellson
AU - Waterfield, Michael D.
AU - Francke, Uta
AU - Ullrich, Axel
PY - 1986
Y1 - 1986
N2 - A new family of protein kinase C - related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.
AB - A new family of protein kinase C - related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.
UR - http://www.scopus.com/inward/record.url?scp=0022504365&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022504365&partnerID=8YFLogxK
U2 - 10.1126/science.3755548
DO - 10.1126/science.3755548
M3 - Article
C2 - 3755548
AN - SCOPUS:0022504365
SN - 0036-8075
VL - 233
SP - 859
EP - 866
JO - Science
JF - Science
IS - 4766
ER -