Multiple gestations in assisted reproductive technology: Can they be avoided with blastocyst transfers?

Marsha J. Gorrill, Karen Sadler-Fredd, Phillip E. Patton, Kenneth A. Burry

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


OBJECTIVE: Blastocysts are advanced-stage embryos with high implantation potential; theoretically, limited numbers of blastocysts can be used for embryo transfer to achieve good pregnancy rates with low multiple pregnancy rates. Clinical outcomes of a newly implemented blastocyst transfer program were evaluated. STUDY DESIGN: This study is a retrospective analysis of 553 blastocyst transfer cycles performed by a university-based in vitro fertilization program; risk factors associated with multiple gestations were analyzed. RESULTS: An average of 2.2 embryos were used for embryo transfer. The overall clinical pregnancy rate per embryo transfer was 45.1%; multiple gestation, twin, and triplet rates were 40.9%, 36.5%, and 4.3%, respectively. Multiple gestations increased significantly (1) when embryo transfer was done on day 5, (2) when ≥2 blastocysts were present on day 5, and (3) when maternal age was ≤30 years. CONCLUSION: In spite of a conservative approach to the number of blastocysts used for embryo transfer, the overall multiple pregnancy rate was high, and triplet pregnancies did occur.

Original languageEnglish (US)
Pages (from-to)1471-1477
Number of pages7
JournalAmerican journal of obstetrics and gynecology
Issue number7
StatePublished - Jan 1 2001


  • Blastocyst transfer
  • In vitro fertilization
  • Multiple gestation

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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