TY - JOUR
T1 - Myc-driven murine prostate cancer shares molecular features with human prostate tumors
AU - Ellwood-Yen, Katharine
AU - Graeber, Thomas G.
AU - Wongvipat, John
AU - Iruela-Arispe, M. Luisa
AU - Zhang, Jian Feng
AU - Matusik, Robert
AU - Thomas, George V.
AU - Sawyers, Charles L.
N1 - Funding Information:
We wish to thank Dr. Robert Cardiff and Dr. Scott Shappell for helpful discussions on mouse prostate pathology and Dr. David Eisenberg for support and critical discussion. K.E.-Y. is supported by a fellowship grant from the California Cancer Research Program (00-00748V-20082). G.V.T. is supported by a U.S Department of Defense prostate cancer research program (DAMD17-02-1-0027) and a UCLA Prostate SPORE Career Development grant. C.L.S. is an Investigator of the Howard Hughes Medical Institute and a Doris Duke Distinguished Scientist. Work in his laboratory is also supported by grants from the National Cancer Institute and the U.S. Department of Defense.
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Increased Myc gene copy number is observed in human prostate cancer. To define Myc's functional role, we generated transgenic mice expressing human c-Myc in the mouse prostate. All mice developed murine prostatic intraepithelial neoplasia followed by invasive adenocarcinoma. Microarray-based expression profiling identified a Myc prostate cancer expression signature, which included the putative human tumor suppressor NXK3.1. Human prostate tumor databases revealed modules of human genes that varied in concert with the Myc prostate cancer signature. This module includes the Pim-1 kinase, a gene known to cooperate with Myc in tumorigenesis, and defines a subset of human, "Myc-like" human cancers. This approach illustrates how genomic technologies can be applied to mouse cancer models to guide evaluation of human tumor databases.
AB - Increased Myc gene copy number is observed in human prostate cancer. To define Myc's functional role, we generated transgenic mice expressing human c-Myc in the mouse prostate. All mice developed murine prostatic intraepithelial neoplasia followed by invasive adenocarcinoma. Microarray-based expression profiling identified a Myc prostate cancer expression signature, which included the putative human tumor suppressor NXK3.1. Human prostate tumor databases revealed modules of human genes that varied in concert with the Myc prostate cancer signature. This module includes the Pim-1 kinase, a gene known to cooperate with Myc in tumorigenesis, and defines a subset of human, "Myc-like" human cancers. This approach illustrates how genomic technologies can be applied to mouse cancer models to guide evaluation of human tumor databases.
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U2 - 10.1016/S1535-6108(03)00197-1
DO - 10.1016/S1535-6108(03)00197-1
M3 - Article
C2 - 14522256
AN - SCOPUS:0141569009
SN - 1535-6108
VL - 4
SP - 223
EP - 238
JO - Cancer Cell
JF - Cancer Cell
IS - 3
ER -