Abstract
Immunomodulating agents interact with the immune system and alter the outcome of specific immune processes. As our understanding of the immune system continues to evolve, there is a growing effort to identify agents with immunomodulating applications to use therapeutically to treat various diseases. Mycobacterium w (Mw), a heat-killed mycobacterium, is an atypical mycobacterial species that possesses strong immunomodulatory properties. Mw was initially evaluated as an immune-therapeutic against leprosy, but since then Mw has generated a lot of interest and been studied for therapeutic applications across a host of diseases, such as pulmonary tuberculosis, tuberculous pericarditis, sepsis, lung cancer, and more. This article summarizes a large body of work published in the past five decades, describing various aspects of Mw and its potential for further therapeutic development.
Original language | English (US) |
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Article number | 1450118 |
Journal | Frontiers in immunology |
Volume | 15 |
DOIs | |
State | Published - 2024 |
Keywords
- COVID-19
- Mycobacterium w
- cancer
- immune therapy
- leprosy
- tuberculosis
- vaccine
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology