TY - JOUR
T1 - Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in buffalo rats
AU - Jones, Richard E.
AU - Bourdette, Dennis N.
AU - Offner, Halina
AU - Vandenbark, Arthur A.
PY - 1990/11
Y1 - 1990/11
N2 - This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1b) following techniques used to develop similar lines from Lewis rats (Rt-1l). Unlike those of Lewis those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines, Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses.
AB - This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1b) following techniques used to develop similar lines from Lewis rats (Rt-1l). Unlike those of Lewis those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines, Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses.
KW - (Buffalo rat)
KW - Demyelination
KW - Experimental autoimmune encephalomyelitis
KW - Passive immunization
UR - https://www.scopus.com/pages/publications/0025064527
UR - https://www.scopus.com/pages/publications/0025064527#tab=citedBy
U2 - 10.1016/0165-5728(90)90053-P
DO - 10.1016/0165-5728(90)90053-P
M3 - Article
C2 - 1699972
AN - SCOPUS:0025064527
SN - 0165-5728
VL - 30
SP - 61
EP - 69
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1
ER -