Myelin changes in the rats CNS following intraventricular injection of serum

G. Konat; N. H. Diemer; H. Offner

doi:10.1007/BF01975883

Myelin changes in the rats CNS following intraventricular injection of serum

G. Konat, N. H. Diemer, H. Offner

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.

Original language	English (US)
Pages (from-to)	37-39
Number of pages	3
Journal	Experientia
Volume	42
Issue number	1
DOIs	https://doi.org/10.1007/BF01975883
State	Published - Jan 1986
Externally published	Yes

Keywords

CNS
Serum
demyelination
dissociated myelin
intrathecal injection
multiple sclerosis

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/BF01975883

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title = "Myelin changes in the rats CNS following intraventricular injection of serum",

abstract = "Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.",

keywords = "CNS, Serum, demyelination, dissociated myelin, intrathecal injection, multiple sclerosis",

author = "G. Konat and Diemer, {N. H.} and H. Offner",

year = "1986",

month = jan,

doi = "10.1007/BF01975883",

language = "English (US)",

volume = "42",

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T1 - Myelin changes in the rats CNS following intraventricular injection of serum

AU - Konat, G.

AU - Diemer, N. H.

AU - Offner, H.

PY - 1986/1

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N2 - Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.

AB - Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.

KW - CNS

KW - Serum

KW - demyelination

KW - dissociated myelin

KW - intrathecal injection

KW - multiple sclerosis

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Myelin changes in the rats CNS following intraventricular injection of serum

Abstract

Keywords

ASJC Scopus subject areas

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