Myometrial activation and preterm labour: Evidence supporting a role for the prostaglandin F receptor - A review

David M. Olson; D. B. Zaragoza; M. C. Shallow; J. L. Cook; B. F. Mitchell; P. Grigsby; J. Hirst

doi:10.1053/plac.2002.0938

Myometrial activation and preterm labour: Evidence supporting a role for the prostaglandin F receptor - A review

David M. Olson, D. B. Zaragoza, M. C. Shallow, J. L. Cook, B. F. Mitchell, P. Grigsby, J. Hirst

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

An increase in the myometrial expression of the prostaglandin (PG) receptors, and especially the PGF_2α receptor (FP), may be an important component of the process initiating preterm labour. In this review of the literature and presentation of new possibilities, evidence will be discussed that demonstrates an increase in mouse uterine FP mRNA occurs at preterm birth whereas uterine PGF_2α concentrations do not increase, suggesting elevated uterine receptor expression and sensitivity is a mechanism for preterm labour initiation. The first examination of the complete human myometrial FP promoter will be described and evidence presented that demonstrates the pro-inflammatory cytokine, interleukin-1β, stimulates FP mRNA expression. Finally new data showing that administration of a specific FP antagonist delays preterm birth in sheep will be presented.

Original language	English (US)
Pages (from-to)	S47-S54
Journal	Placenta
Volume	24
Issue number	SUPPL. A
DOIs	https://doi.org/10.1053/plac.2002.0938
State	Published - Apr 2003
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology
Developmental Biology

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10.1053/plac.2002.0938

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title = "Myometrial activation and preterm labour: Evidence supporting a role for the prostaglandin F receptor - A review",

abstract = "An increase in the myometrial expression of the prostaglandin (PG) receptors, and especially the PGF2α receptor (FP), may be an important component of the process initiating preterm labour. In this review of the literature and presentation of new possibilities, evidence will be discussed that demonstrates an increase in mouse uterine FP mRNA occurs at preterm birth whereas uterine PGF2α concentrations do not increase, suggesting elevated uterine receptor expression and sensitivity is a mechanism for preterm labour initiation. The first examination of the complete human myometrial FP promoter will be described and evidence presented that demonstrates the pro-inflammatory cytokine, interleukin-1β, stimulates FP mRNA expression. Finally new data showing that administration of a specific FP antagonist delays preterm birth in sheep will be presented.",

author = "Olson, {David M.} and Zaragoza, {D. B.} and Shallow, {M. C.} and Cook, {J. L.} and Mitchell, {B. F.} and P. Grigsby and J. Hirst",

note = "Funding Information: The authors are funded by the Canadian Institutes of Health Research, the Alberta Heritage Foundation for Medical Research, and the National Health and Medical Research Council of Australia. Dr Krishna Peri of Theratechnologies kindly provided THG113.31a. Ms Sheila McManus provided valuable assistance with the preparation of the manuscript.",

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AU - Cook, J. L.

AU - Mitchell, B. F.

AU - Grigsby, P.

AU - Hirst, J.

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Myometrial activation and preterm labour: Evidence supporting a role for the prostaglandin F receptor - A review

Abstract

ASJC Scopus subject areas

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