@inproceedings{965f80a89a514e079637c9e2feb912e7,
title = "Nanoplasmonic biomolecular ruler with a 2 NM spatial resolution for probing restricted digestion of nucleic acids",
abstract = "One of the major challenges of quantitative biochemistry and molecular biology is to monitor enzymatic activity within a femtoliter volume in real time. We have constructed a novel nanoscale plasmonic probe-based molecular ruler, which can perform label-free, real-time, and sensitive monitoring of DNA footprint or length during nuclease enzymatic reactions occurring around single nanoplasmonic biomolecular ruler. The nanoplasmonic molecular ruler was created by tethering specifically-designed double-stranded DNA to single Au nanoparticles. DNA length differences of as little as 2 nm (6 base pairs) after nuclease digestion are differentiated by the corresponding plasmon resonance shifts of the Au-DNA nanoconjugate.",
keywords = "Nanoparticles, Nuclease, Nucleic acids, Plasmon resonance",
author = "Liu, {Gang L.} and Fanqing Chen and Daniele Gerion and Yadong Yin and {Paul Alivisatos}, A. and Gray, {Joe W.} and Lee, {Luke P.}",
year = "2005",
language = "English (US)",
isbn = "0974361119",
series = "Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Transducer Research Foundation",
pages = "1513--1515",
booktitle = "Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference",
note = "9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 ; Conference date: 09-10-2005 Through 13-10-2005",
}