Neonatal leukocyte cAMP‐phosphodiesterase determination is not suitable for allergy prediction

H. Odelram; B. Björksten; S. C. Chan; J. M. Hanifin; N. ‐I M. Kjellman

doi:10.1111/j.1398-9995.1994.tb00141.x

Neonatal leukocyte cAMP‐phosphodiesterase determination is not suitable for allergy prediction

H. Odelram, B. Björksten, S. C. Chan, J. M. Hanifin, N. ‐I M. Kjellman

Dermatology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The atopy‐predictive value of cord blood (CB) cyclic adenosine monophosphate‐phosphodiesterase (cAMP‐PDE) in mononuclear leukocytes (MN) was studied prospectively in 57 neonates. Reliable determination of cAMP‐PDE was achieved in only 20 CB samples. The levels tended to be higher in infants developing signs of atopy up to 18 months of age. The combination of CB cAMP‐PDE and family history (FH) of allergy showed a higher predictive value (P = 0.040) than each of them separately (P= 0.370 and P= 0.102, respectively). The cAMP‐PDE levels in CB also correlated to FH of allergy/atopy in accordance with earlier studies (P = 0.027). In conclusion, determination of cAMP‐PDE in neonates may have some predictive value, but it is not suitable for general screening.

Original language	English (US)
Pages (from-to)	677-679
Number of pages	3
Journal	Allergy
Volume	49
Issue number	8
DOIs	https://doi.org/10.1111/j.1398-9995.1994.tb00141.x
State	Published - Sep 1994

Keywords

allergy
cAMP‐phosphodiesterase
infants
neonatal screening tests
prediction

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1111/j.1398-9995.1994.tb00141.x

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title = "Neonatal leukocyte cAMP‐phosphodiesterase determination is not suitable for allergy prediction",

abstract = "The atopy‐predictive value of cord blood (CB) cyclic adenosine monophosphate‐phosphodiesterase (cAMP‐PDE) in mononuclear leukocytes (MN) was studied prospectively in 57 neonates. Reliable determination of cAMP‐PDE was achieved in only 20 CB samples. The levels tended to be higher in infants developing signs of atopy up to 18 months of age. The combination of CB cAMP‐PDE and family history (FH) of allergy showed a higher predictive value (P = 0.040) than each of them separately (P= 0.370 and P= 0.102, respectively). The cAMP‐PDE levels in CB also correlated to FH of allergy/atopy in accordance with earlier studies (P = 0.027). In conclusion, determination of cAMP‐PDE in neonates may have some predictive value, but it is not suitable for general screening.",

keywords = "allergy, cAMP‐phosphodiesterase, infants, neonatal screening tests, prediction",

author = "H. Odelram and B. Bj{\"o}rksten and Chan, {S. C.} and Hanifin, {J. M.} and Kjellman, {N. ‐I M.}",

year = "1994",

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doi = "10.1111/j.1398-9995.1994.tb00141.x",

language = "English (US)",

volume = "49",

pages = "677--679",

journal = "Allergy",

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AU - Odelram, H.

AU - Björksten, B.

AU - Chan, S. C.

AU - Hanifin, J. M.

AU - Kjellman, N. ‐I M.

PY - 1994/9

Y1 - 1994/9

N2 - The atopy‐predictive value of cord blood (CB) cyclic adenosine monophosphate‐phosphodiesterase (cAMP‐PDE) in mononuclear leukocytes (MN) was studied prospectively in 57 neonates. Reliable determination of cAMP‐PDE was achieved in only 20 CB samples. The levels tended to be higher in infants developing signs of atopy up to 18 months of age. The combination of CB cAMP‐PDE and family history (FH) of allergy showed a higher predictive value (P = 0.040) than each of them separately (P= 0.370 and P= 0.102, respectively). The cAMP‐PDE levels in CB also correlated to FH of allergy/atopy in accordance with earlier studies (P = 0.027). In conclusion, determination of cAMP‐PDE in neonates may have some predictive value, but it is not suitable for general screening.

AB - The atopy‐predictive value of cord blood (CB) cyclic adenosine monophosphate‐phosphodiesterase (cAMP‐PDE) in mononuclear leukocytes (MN) was studied prospectively in 57 neonates. Reliable determination of cAMP‐PDE was achieved in only 20 CB samples. The levels tended to be higher in infants developing signs of atopy up to 18 months of age. The combination of CB cAMP‐PDE and family history (FH) of allergy showed a higher predictive value (P = 0.040) than each of them separately (P= 0.370 and P= 0.102, respectively). The cAMP‐PDE levels in CB also correlated to FH of allergy/atopy in accordance with earlier studies (P = 0.027). In conclusion, determination of cAMP‐PDE in neonates may have some predictive value, but it is not suitable for general screening.

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KW - cAMP‐phosphodiesterase

KW - infants

KW - neonatal screening tests

KW - prediction

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Neonatal leukocyte cAMP‐phosphodiesterase determination is not suitable for allergy prediction

Abstract

Keywords

ASJC Scopus subject areas

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