Neoplastic transformation in vitro of hamster lens epithelium by simian virus 40

Daniel M. Albert; Alan S. Rabson; Patricia A. Grimes; Ludwig Von Sallmann

doi:10.1126/science.164.3883.1077

Neoplastic transformation in vitro of hamster lens epithelium by simian virus 40

Daniel M. Albert, Alan S. Rabson, Patricia A. Grimes, Ludwig Von Sallmann

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Abstract

Hamster lens epithelium infected with simian virus 40 underwent transformation in vitro and produced tumors when injected into homologous hosts. Undisturbed lens epithelium in man and experimental animals has not been observed to undergo neoplastic change. The virus-induced tumors contained undifferentiated cells that were either polygonal or spindle-shaped. Their origin from lens epithelium seems certain since it is possible to isolate this unique structure free of connective tissue and blood vessels.

Original language	English (US)
Pages (from-to)	1077-1078
Number of pages	2
Journal	Science
Volume	164
Issue number	3883
DOIs	https://doi.org/10.1126/science.164.3883.1077
State	Published - 1969
Externally published	Yes

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title = "Neoplastic transformation in vitro of hamster lens epithelium by simian virus 40",

abstract = "Hamster lens epithelium infected with simian virus 40 underwent transformation in vitro and produced tumors when injected into homologous hosts. Undisturbed lens epithelium in man and experimental animals has not been observed to undergo neoplastic change. The virus-induced tumors contained undifferentiated cells that were either polygonal or spindle-shaped. Their origin from lens epithelium seems certain since it is possible to isolate this unique structure free of connective tissue and blood vessels.",

author = "Albert, {Daniel M.} and Rabson, {Alan S.} and Grimes, {Patricia A.} and {Von Sallmann}, Ludwig",

year = "1969",

doi = "10.1126/science.164.3883.1077",

language = "English (US)",

volume = "164",

pages = "1077--1078",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "3883",

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T1 - Neoplastic transformation in vitro of hamster lens epithelium by simian virus 40

AU - Albert, Daniel M.

AU - Rabson, Alan S.

AU - Grimes, Patricia A.

AU - Von Sallmann, Ludwig

PY - 1969

Y1 - 1969

N2 - Hamster lens epithelium infected with simian virus 40 underwent transformation in vitro and produced tumors when injected into homologous hosts. Undisturbed lens epithelium in man and experimental animals has not been observed to undergo neoplastic change. The virus-induced tumors contained undifferentiated cells that were either polygonal or spindle-shaped. Their origin from lens epithelium seems certain since it is possible to isolate this unique structure free of connective tissue and blood vessels.

AB - Hamster lens epithelium infected with simian virus 40 underwent transformation in vitro and produced tumors when injected into homologous hosts. Undisturbed lens epithelium in man and experimental animals has not been observed to undergo neoplastic change. The virus-induced tumors contained undifferentiated cells that were either polygonal or spindle-shaped. Their origin from lens epithelium seems certain since it is possible to isolate this unique structure free of connective tissue and blood vessels.

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ER -

Neoplastic transformation in vitro of hamster lens epithelium by simian virus 40

Abstract

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