TY - JOUR
T1 - Nephrotoxicity of the flame retardant, tris(2,3-dibromopropyl) phosphate, and its metabolites
AU - Elliott, W. Clayton
AU - Lynn, Robert K.
AU - Houghton, Donald C.
AU - Kennish, John M.
AU - Bennett, William M.
N1 - Funding Information:
The authors gratefully acknowledge the technical assistance of J. DeFehr, K. Kuettner, and J. Kimsey and the secretarial expertise of J. Paquet. This work was supported, in part, by NIEHS Contract NOl-ES-‘I-2126.
PY - 1982/1
Y1 - 1982/1
N2 - A single ip injection of the carcinogenic flame retardant, tris(2,3-dibromopropyl) phosphate (TRIS-BP), when administered to male Sprague-Dawley rats, caused polyuric acute renal failure with tubular necrosis involving the late proximal tubule. Glomerular filtration rate and in vitro transport of the organic acid, para-aminohippurate and the organic base, N-[14C]methylnicotinamide, were depressed. An approximately equimolar dose of the TRIS-BP metabolite, bis(2,3-dibromopropyl) phosphate (BIS-BP), caused significantly more severe renal failure. In contrast, the metabolite 2,3-dibromopropanol (BP) was nonnephrotoxic. These data suggest that TRIS-BP nephrotoxicity is mediated via its metabolite BIS-BP.
AB - A single ip injection of the carcinogenic flame retardant, tris(2,3-dibromopropyl) phosphate (TRIS-BP), when administered to male Sprague-Dawley rats, caused polyuric acute renal failure with tubular necrosis involving the late proximal tubule. Glomerular filtration rate and in vitro transport of the organic acid, para-aminohippurate and the organic base, N-[14C]methylnicotinamide, were depressed. An approximately equimolar dose of the TRIS-BP metabolite, bis(2,3-dibromopropyl) phosphate (BIS-BP), caused significantly more severe renal failure. In contrast, the metabolite 2,3-dibromopropanol (BP) was nonnephrotoxic. These data suggest that TRIS-BP nephrotoxicity is mediated via its metabolite BIS-BP.
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U2 - 10.1016/0041-008X(82)90115-6
DO - 10.1016/0041-008X(82)90115-6
M3 - Article
C2 - 7064152
AN - SCOPUS:0020038871
SN - 0041-008X
VL - 62
SP - 179
EP - 182
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
IS - 1
ER -