Abstract
Spontaneous neuronal activity plays an important role in the development of cortical circuitry, yet its spatio-temporal dynamics are poorly understood. Cajal-Retziua (CR) neurons in developing layer I are necessary for correct cortical lamination and are strategically located to coordinate early circuit activity. To characterize the spontaneous activity of CR and other layer I neurons during cortical development, we imaged calcium transients in populations of layer 1 neurons in hemispheres and slices from postnatal rat somatosensory neocortex. The spontaneous activity in layer 1 had complex spatio-temporal patterns. Groups of non-CR cells showed synchronous activations and formed networks of correlated neurons superimposed in the same territory. Correlated activity among non-CR cells was mediated by a depolarizing effect of GABA and was modulated by glutamate, probably released by CR cells. Our findings demonstrate that developing layer 1 can sustain complex patterns of correlated activity and reveal a circuit mechanism that can mediate this patterned activity.
Original language | English (US) |
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Pages (from-to) | 541-552 |
Number of pages | 12 |
Journal | Neuron |
Volume | 20 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1998 |
Externally published | Yes |
ASJC Scopus subject areas
- General Neuroscience