Neurobiological consequences of long-term estrogen therapy

L. K. Marriott, Gary L. Wenk

Research output: Contribution to journalReview articlepeer-review


Postmenopausal women demonstrate an increased incidence of Alzheimer's disease (AD). Epidemiological evidence suggests that estrogen replacement therapy (ERT) may reduce the risk or delay the onset of AD, yet recent clinical trials found no cognitive benefits of ERT in women with mild to moderate AD. This review suggests that the timing of estrogen administration may explain these conflicting results. Chronic administration has neurobiological consequences that can affect neural and immune function, but a therapy designed to mimic the natural cycle of fluctuating hormones may more effectively slow the progression of AD in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalCurrent Directions in Psychological Science
Issue number5
StatePublished - Oct 2004
Externally publishedYes


  • Alzheimer's disease
  • Estrogen
  • Immune
  • Luteinizing hormone (LH)
  • Neuroprotection

ASJC Scopus subject areas

  • Psychology(all)


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