Neurocognitive functioning and magnetic resonance imaging in children with sickle cell disease

Ronald T. Brown, Patricia C. Davis, Richard Lambert, Lewis Hsu, Katharine Hopkins, James Eckman

Research output: Contribution to journalArticlepeer-review

109 Scopus citations


Objective: To examine neurocognitive functioning in children classified with overt cerebral vascular accidents (CVAs), silent infarcts, or without central nervous system (CNS) pathology on magnetic resonance imaging. Methods: Participants were 63 children and adolescents with sickle cell disease (SCD). Results: Children with overt CVAs and silent infarcts differed from their peers without CNS pathology on measures of attention and executive functioning. Conclusions: We consider these deficits the result of the high frequency of frontal lobe deficits incurred by children with SCD. Recommendations include the use of tests designed to measure attention and executive functioning as a way of screening children with SCD for possible CNS pathology. We also suggest that future research examine the mechanism underlying frontal lobe involvement for individuals with SCD.

Original languageEnglish (US)
Pages (from-to)503-513
Number of pages11
JournalJournal of pediatric psychology
Issue number7
StatePublished - 2000
Externally publishedYes


  • Attention
  • Cerebral vascular accident
  • Neurocognitive
  • Sickle cell disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology


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