Neuropathology in the adult changes in thought study: A review

Joshua A. Sonnen; Eric B. Larson; Sebastien Haneuse; Randy Woltjer; Ge Li; Paul K. Crane; Suzanne Craft; Thomas J. Montine

doi:10.3233/JAD-2009-1180

Neuropathology in the adult changes in thought study: A review

Joshua A. Sonnen, Eric B. Larson, Sebastien Haneuse, Randy Woltjer, Ge Li, Paul K. Crane, Suzanne Craft, Thomas J. Montine

Pathology

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

The neuropathology underlying dementia syndromes in older populations is complex. The contributions of Alzheimer's and Lewy body pathology are well appreciated. Recent studies with brain autopsies have highlighted the high prevalence of vascular disease as an independent, but often co-morbid contributor to dementia. The Adult Changes in Thought Study is a community-based, longitudinal study of brain aging and cognitive decline which has recently confirmed cerebral microinfarcts as a strong correlate of cognitive impairment and dementia. This study examines correlations between clinical characteristics including extensive, longitudinal medication histories, and longitudinal cognitive testing against structural and biochemical features of disease.

Original language	English (US)
Pages (from-to)	703-711
Number of pages	9
Journal	Journal of Alzheimer's Disease
Volume	18
Issue number	3
DOIs	https://doi.org/10.3233/JAD-2009-1180
State	Published - 2009

Keywords

Aging
Community-based
Longitudinal
Microinfarct
Neuropathology

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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abstract = "The neuropathology underlying dementia syndromes in older populations is complex. The contributions of Alzheimer's and Lewy body pathology are well appreciated. Recent studies with brain autopsies have highlighted the high prevalence of vascular disease as an independent, but often co-morbid contributor to dementia. The Adult Changes in Thought Study is a community-based, longitudinal study of brain aging and cognitive decline which has recently confirmed cerebral microinfarcts as a strong correlate of cognitive impairment and dementia. This study examines correlations between clinical characteristics including extensive, longitudinal medication histories, and longitudinal cognitive testing against structural and biochemical features of disease.",

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AU - Li, Ge

AU - Crane, Paul K.

AU - Craft, Suzanne

AU - Montine, Thomas J.

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AB - The neuropathology underlying dementia syndromes in older populations is complex. The contributions of Alzheimer's and Lewy body pathology are well appreciated. Recent studies with brain autopsies have highlighted the high prevalence of vascular disease as an independent, but often co-morbid contributor to dementia. The Adult Changes in Thought Study is a community-based, longitudinal study of brain aging and cognitive decline which has recently confirmed cerebral microinfarcts as a strong correlate of cognitive impairment and dementia. This study examines correlations between clinical characteristics including extensive, longitudinal medication histories, and longitudinal cognitive testing against structural and biochemical features of disease.

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Neuropathology in the adult changes in thought study: A review

Abstract

Keywords

ASJC Scopus subject areas

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