Neuropeptide y and gamma-melanocyte stimulating hormone (γ-MSH) share a common pressor mechanism of action

Kenneth A. Gruber, Wei Fan, Helena Akerberg, Dan Larhammar, Melissa J.S. Chee, William F. Colmers, Roger D. Cone

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Central circuits known to regulate food intake and energy expenditure also affect central cardiovascular regulation. For example, both the melanocortin and neuropeptide Y (NPY) peptide families, known to regulate food intake, also produce central hypertensive effects. Members of both families share a similar C-terminal amino acid residue sequence, RF(Y) amide, a sequence distinct from that required for melanocortin receptor binding. A recently delineated family of RFamide receptors recognizes both of these C-terminal motifs. We now present evidence that an antagonist with Y1 and RFamide receptor activity, BIBO3304, will attenuate the central cardiovascular effects of both gamma-melanocyte stimulating hormone (γ-MSH) and NPY. The use of synthetic melanocortin and NPY peptide analogs excluded an interaction with melanocortin or Y family receptors. We suggest that the anatomical convergence of NPY and melanocortin neurons on cardiovascular control centers may have pathophysiological implications through a common or similar RFamide receptor(s), much as they converge on other nuclei to coordinately control energy homeostasis.

Original languageEnglish (US)
Pages (from-to)312-324
Number of pages13
Issue number3
StatePublished - Jun 2009
Externally publishedYes


  • Central nervous system
  • Central vasopressin system
  • Hypertensive effects
  • Neuropeptide Y
  • RFamide peptides
  • RFamide receptors
  • Y1 antagonists
  • γ-MSH

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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