P. S. Spencer, P. J. Lein

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations


Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the nervous system of animals. Some act directly on neural cells, others interfere with metabolic processes on which the nervous system is especially dependent. Some disrupt neural function, others induce maldevelopment or damage to the adult nervous system. Perturbations may appear and disappear rapidly, evolve slowly over days or weeks and regress over months or years, or cause permanent deficits. Neurotoxicity is usually self-limiting after exposure ceases and rarely progressive in the absence of continued exposure, although there may be a significant delay between exposure and manifestation of neurotoxic effects.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Toxicology
Subtitle of host publicationThird Edition
Number of pages12
ISBN (Electronic)9780123864543
ISBN (Print)9780123864550
StatePublished - Jan 1 2014


  • Aging
  • Autism
  • Bacterium
  • Blood-brain barrier
  • Brain
  • Development
  • Environment
  • Fungus
  • Invertebrate
  • Nerve
  • Neurodegeneration
  • Neuropathy
  • Occupation
  • Plant
  • Vertebrate

ASJC Scopus subject areas

  • Medicine(all)


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