Neurotransmitter receptors I: The metabotropic glutamate receptors: Structure and functions

J. P. Pin, R. Duvoisin

Research output: Contribution to journalReview articlepeer-review

1240 Scopus citations


Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels - termed NMDA, AMPA and kainate receptors - involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins. The existence of these receptors, called metabotropic glutamate receptors, is changing our views on the functioning of fast excitatory synapses.

Original languageEnglish (US)
Pages (from-to)1-26
Number of pages26
Issue number1
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience


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