@article{71839ea77f1940cab0610ca91724baa8,
title = "Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum",
abstract = "SARS-CoV-2 and its variants continue to infect hundreds of thousands every day despite the rollout of effective vaccines. Therefore, it is essential to understand the levels of protection that these vaccines provide in the face of emerging variants. Here, we report two demographically balanced cohorts of BNT162b2 vaccine recipients and COVID-19 patients, from which we evaluate neutralizing antibody titers against SARS-CoV-2 as well as the B.1.1.7 (alpha) and B.1.351 (beta) variants. We show that both B.1.1.7 and B.1.351 are less well neutralized by serum from vaccinated individuals, and that B.1.351, but not B.1.1.7, is less well neutralized by convalescent serum. We also find that the levels of variant-specific anti-spike antibodies are proportional to neutralizing activities. Together, our results demonstrate the escape of the emerging SARS-CoV-2 variants from neutralization by serum antibodies, which may lead to reduced protection from re-infection or increased risk of vaccine breakthrough.",
author = "Bates, {Timothy A.} and Leier, {Hans C.} and Lyski, {Zoe L.} and McBride, {Savannah K.} and Coulter, {Felicity J.} and Weinstein, {Jules B.} and Goodman, {James R.} and Zhengchun Lu and Siegel, {Sarah A.R.} and Peter Sullivan and Matt Strnad and Brunton, {Amanda E.} and Lee, {David X.} and Adey, {Andrew C.} and Bimber, {Benjamin N.} and O{\textquoteright}Roak, {Brian J.} and Curlin, {Marcel E.} and Messer, {William B.} and Tafesse, {Fikadu G.}",
note = "Funding Information: The authors thank the generous contribution of the many patients and vaccinees who participated in this study. In addition, we gratefully acknowledge the efforts of the entire OHSU COVID-19 serology study team. We also want to thank the following members of the Oregon SARS-CoV-2 Genome Sequencing Center at OHSU for their help in sequencing our samples: Sonia N. Acharya, Cierra N. LaBlanc, Kayla I. Carter, Sally Grindstaff, Brendan L. O{\textquoteright}Connell, and Ruth V. Nichols. This study was funded in part by an unrestricted grant from the M.J. Murdock Charitable Trust, by NIH training grant T32AI747225 on Interactions at the Microbe-Host Interface, and OHSU Innovative IDEA grant 1018784, and NIH R01AI145835. Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = dec,
day = "1",
doi = "10.1038/s41467-021-25479-6",
language = "English (US)",
volume = "12",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}