New developments in uveitis associated with HLA B27

James T. Rosenbaum

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Purpose of review Uveitis is the most common, clinically apparent, extra-articular manifestation of axial spondyloarthritis. This review summarizes recent publications related to this form of uveitis. Recent findings Studies published since the start of 2015 address the worldwide prevalence of human leukocyte antigen (HLA) B27-associated uveitis, the prevalence of axial spondyloarthritis among patients with B27-associated acute anterior uveitis (AAU), the genetics of AAU and some of the clinical implications of AAU. Progress has been made in the treatment of uveitis in general and in the treatment of uveitis in association with spondyloarthropathy in particular. The pathogenesis of AAU might derive clues from the above as well as from an understanding of the microbiome and possibly from knowledge derived from uveitis in association with Ebola. Summary Although HLA B27-associated uveitis has been recognized since 1973, a variety of recent observations shed new light on this common clinical association with spondyloarthritis.

Original languageEnglish (US)
Pages (from-to)298-303
Number of pages6
JournalCurrent opinion in rheumatology
Issue number4
StatePublished - Jul 1 2017


  • HLA B27
  • ankylosing spondylitis
  • iritis
  • uveitis

ASJC Scopus subject areas

  • Rheumatology


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