New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Yingchang Lu; Felix R. Day; Stefan Gustafsson; Martin L. Buchkovich; Jianbo Na; Veronique Bataille; Diana L. Cousminer; Zari Dastani; Alexander W. Drong; Toñu Esko; David M. Evans; Mario Falchi; Mary F. Feitosa; Teresa Ferreira; Åsa K. Hedman; Robin Haring; Pirro G. Hysi; Mark M. Iles; Anne E. Justice; Stavroula Kanoni; Vasiliki Lagou; Rui Li; Xin Li; Adam Locke; Chen Lu; Reedik Mägi; John R.B. Perry; Tune H. Pers; Qibin Qi; Marianna Sanna; Ellen M. Schmidt; William R. Scott; Dmitry Shungin; Alexander Teumer; Anna A.E. Vinkhuyzen; Ryan W. Walker; Harm Jan Westra; Mingfeng Zhang; Weihua Zhang; Jing Hua Zhao; Zhihong Zhu; Uzma Afzal; Tarunveer Singh Ahluwalia; Stephan J.L. Bakker; Claire Bellis; Amélie Bonnefond; Katja Borodulin; Aron S. Buchman; Tommy Cederholm; Audrey C. Choh; Hyung Jin Choi; Joanne E. Curran; Lisette C.P.G.M. De Groot; Philip L. De Jager; Rosalie A.M. Dhonukshe-Rutten; Anke W. Enneman; Elodie Eury; Daniel S. Evans; Tom Forsen; Nele Friedrich; Frédéric Fumeron; Melissa E. Garcia; Simone Gärtner; Bok Ghee Han; Aki S. Havulinna; Caroline Hayward; Dena Hernandez; Hans Hillege; Till Ittermann; Jack W. Kent; Ivana Kolcic; Tiina Laatikainen; Jari Lahti; Irene Mateo Leach; Christine G. Lee; Jong Young Lee; Tian Liu; Youfang Liu; Stéphane Lobbens; Marie Loh; Leo Pekka Lyytikaïnen; Carolina Medina-Gomez; Karl Michaëlsson; Mike A. Nalls; Carrie M. Nielson; Laticia Oozageer; Laura Pascoe; Lavinia Paternoster; Ozren Polašek; Samuli Ripatti; Mark A. Sarzynski; Chan Soo Shin; Nina Smolej Naranäiä; Dominik Spira; Priya Srikanth; Elisabeth Steinhagen-Thiessen; Yun Ju Sung; Karin M.A. Swart; Leena Taittonen; Toshiko Tanaka; Emmi Tikkanen; Nathalie Van Der Velde; Natasja M. Van Schoor; Niek Verweij; Alan F. Wright; Lei Yu; Joseph M. Zmuda; Niina Eklund; Terrence Forrester; Niels Grarup; Anne U. Jackson; Kati Kristiansson; Teemu Kuulasmaa; Johanna Kuusisto; Peter Lichtner; Jian'an Luan; Anubha Mahajan; Satu Männistö; Cameron D. Palmer; Janina S. Ried; Robert A. Scott; Alena Stancáková; Peter J. Wagner; Ayse Demirkan; Angela Döring; Vilmundur Gudnason; Douglas P. Kiel; Brigitte Kühnel; Massimo Mangino; Barbara McKnight; Cristina Menni; Jeffrey R. O'Connell; Ben A. Oostra; Alan R. Shuldiner; Kijoung Song; Liesbeth Vandenput; Cornelia M. Van Duijn; Peter Vollenweider; Charles C. White; Michael Boehnke; Yvonne Boettcher; Richard S. Cooper; Nita G. Forouhi; Christian Gieger; Harald Grallert; Aroon Hingorani; Torben Jørgensen; Pekka Jousilahti; Mika Kivimaki; Meena Kumari; Markku Laakso; Claudia Langenberg; Allan Linneberg; Amy Luke; Colin A. McKenzie; Aarno Palotie; Oluf Pedersen; Annette Peters; Konstantin Strauch; Bamidele O. Tayo; Nicholas J. Wareham; David A. Bennett; Lars Bertram; John Blangero; Matthias Blüher; Claude Bouchard; Harry Campbell; Nam H. Cho; Steven R. Cummings; Stefan A. Czerwinski; Ilja Demuth; Rahel Eckardt; Johan G. Eriksson; Luigi Ferrucci; Oscar H. Franco; Philippe Froguel; Ron T. Gansevoort; Torben Hansen; Tamara B. Harris; Nicholas Hastie; Markku Heliövaara; Albert Hofman; Joanne M. Jordan; Antti Jula; Mika Kähönen; Eero Kajantie; Paul B. Knekt; Seppo Koskinen; Peter Kovacs; Terho Lehtimäki; Lars Lind; Yongmei Liu; Eric S. Orwoll; Clive Osmond; Markus Perola; Louis Pérusse; Olli T. Raitakari; Tuomo Rankinen; D. C. Rao; Treva K. Rice; Fernando Rivadeneira; Igor Rudan; Veikko Salomaa; Thorkild I.A. Sørensen; Michael Stumvoll; Anke Tönjes; Bradford Towne; Gregory J. Tranah; Angelo Tremblay; André G. Uitterlinden; Pim Van Der Harst; Erkki Vartiainen; Jorma S. Viikari; Veronique Vitart; Marie Claude Vohl; Henry Völzke; Mark Walker; Henri Wallaschofski; Sarah Wild; James F. Wilson; Loïc Yengo; D. Timothy Bishop; Ingrid B. Borecki; John C. Chambers; L. Adrienne Cupples; Abbas Dehghan; Panos Deloukas; Ghazaleh Fatemifar; Caroline Fox; Terrence S. Furey; Lude Franke; Jiali Han; David J. Hunter; Juha Karjalainen; Fredrik Karpe; Robert C. Kaplan; Jaspal S. Kooner; Mark I. McCarthy; Joanne M. Murabito; Andrew P. Morris; Julia A.N. Bishop; Kari E. North; Claes Ohlsson; Ken K. Ong; Inga Prokopenko; J. Brent Richards; Eric E. Schadt; Tim D. Spector; Elisabeth Widén; Cristen J. Willer; Jian Yang; Erik Ingelsson; Karen L. Mohlke; Joel N. Hirschhorn; John Andrew Pospisilik; M. Carola Zillikens; Cecilia Lindgren; Tuomas Oskari Kilpelaïnen; Ruth J.F. Loos

doi:10.1038/ncomms10495

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Yingchang Lu, Felix R. Day, Stefan Gustafsson, Martin L. Buchkovich, Jianbo Na, Veronique Bataille, Diana L. Cousminer, Zari Dastani, Alexander W. Drong, Toñu Esko, David M. Evans, Mario Falchi, Mary F. Feitosa, Teresa Ferreira, Åsa K. Hedman, Robin Haring, Pirro G. Hysi, Mark M. Iles, Anne E. Justice, Stavroula KanoniVasiliki Lagou, Rui Li, Xin Li, Adam Locke, Chen Lu, Reedik Mägi, John R.B. Perry, Tune H. Pers, Qibin Qi, Marianna Sanna, Ellen M. Schmidt, William R. Scott, Dmitry Shungin, Alexander Teumer, Anna A.E. Vinkhuyzen, Ryan W. Walker, Harm Jan Westra, Mingfeng Zhang, Weihua Zhang, Jing Hua Zhao, Zhihong Zhu, Uzma Afzal, Tarunveer Singh Ahluwalia, Stephan J.L. Bakker, Claire Bellis, Amélie Bonnefond, Katja Borodulin, Aron S. Buchman, Tommy Cederholm, Audrey C. Choh, Hyung Jin Choi, Joanne E. Curran, Lisette C.P.G.M. De Groot, Philip L. De Jager, Rosalie A.M. Dhonukshe-Rutten, Anke W. Enneman, Elodie Eury, Daniel S. Evans, Tom Forsen, Nele Friedrich, Frédéric Fumeron, Melissa E. Garcia, Simone Gärtner, Bok Ghee Han, Aki S. Havulinna, Caroline Hayward, Dena Hernandez, Hans Hillege, Till Ittermann, Jack W. Kent, Ivana Kolcic, Tiina Laatikainen, Jari Lahti, Irene Mateo Leach, Christine G. Lee, Jong Young Lee, Tian Liu, Youfang Liu, Stéphane Lobbens, Marie Loh, Leo Pekka Lyytikaïnen, Carolina Medina-Gomez, Karl Michaëlsson, Mike A. Nalls, Carrie M. Nielson, Laticia Oozageer, Laura Pascoe, Lavinia Paternoster, Ozren Polašek, Samuli Ripatti, Mark A. Sarzynski, Chan Soo Shin, Nina Smolej Naranäiä, Dominik Spira, Priya Srikanth, Elisabeth Steinhagen-Thiessen, Yun Ju Sung, Karin M.A. Swart, Leena Taittonen, Toshiko Tanaka, Emmi Tikkanen, Nathalie Van Der Velde, Natasja M. Van Schoor, Niek Verweij, Alan F. Wright, Lei Yu, Joseph M. Zmuda, Niina Eklund, Terrence Forrester, Niels Grarup, Anne U. Jackson, Kati Kristiansson, Teemu Kuulasmaa, Johanna Kuusisto, Peter Lichtner, Jian'an Luan, Anubha Mahajan, Satu Männistö, Cameron D. Palmer, Janina S. Ried, Robert A. Scott, Alena Stancáková, Peter J. Wagner, Ayse Demirkan, Angela Döring, Vilmundur Gudnason, Douglas P. Kiel, Brigitte Kühnel, Massimo Mangino, Barbara McKnight, Cristina Menni, Jeffrey R. O'Connell, Ben A. Oostra, Alan R. Shuldiner, Kijoung Song, Liesbeth Vandenput, Cornelia M. Van Duijn, Peter Vollenweider, Charles C. White, Michael Boehnke, Yvonne Boettcher, Richard S. Cooper, Nita G. Forouhi, Christian Gieger, Harald Grallert, Aroon Hingorani, Torben Jørgensen, Pekka Jousilahti, Mika Kivimaki, Meena Kumari, Markku Laakso, Claudia Langenberg, Allan Linneberg, Amy Luke, Colin A. McKenzie, Aarno Palotie, Oluf Pedersen, Annette Peters, Konstantin Strauch, Bamidele O. Tayo, Nicholas J. Wareham, David A. Bennett, Lars Bertram, John Blangero, Matthias Blüher, Claude Bouchard, Harry Campbell, Nam H. Cho, Steven R. Cummings, Stefan A. Czerwinski, Ilja Demuth, Rahel Eckardt, Johan G. Eriksson, Luigi Ferrucci, Oscar H. Franco, Philippe Froguel, Ron T. Gansevoort, Torben Hansen, Tamara B. Harris, Nicholas Hastie, Markku Heliövaara, Albert Hofman, Joanne M. Jordan, Antti Jula, Mika Kähönen, Eero Kajantie, Paul B. Knekt, Seppo Koskinen, Peter Kovacs, Terho Lehtimäki, Lars Lind, Yongmei Liu, Eric S. Orwoll, Clive Osmond, Markus Perola, Louis Pérusse, Olli T. Raitakari, Tuomo Rankinen, D. C. Rao, Treva K. Rice, Fernando Rivadeneira, Igor Rudan, Veikko Salomaa, Thorkild I.A. Sørensen, Michael Stumvoll, Anke Tönjes, Bradford Towne, Gregory J. Tranah, Angelo Tremblay, André G. Uitterlinden, Pim Van Der Harst, Erkki Vartiainen, Jorma S. Viikari, Veronique Vitart, Marie Claude Vohl, Henry Völzke, Mark Walker, Henri Wallaschofski, Sarah Wild, James F. Wilson, Loïc Yengo, D. Timothy Bishop, Ingrid B. Borecki, John C. Chambers, L. Adrienne Cupples, Abbas Dehghan, Panos Deloukas, Ghazaleh Fatemifar, Caroline Fox, Terrence S. Furey, Lude Franke, Jiali Han, David J. Hunter, Juha Karjalainen, Fredrik Karpe, Robert C. Kaplan, Jaspal S. Kooner, Mark I. McCarthy, Joanne M. Murabito, Andrew P. Morris, Julia A.N. Bishop, Kari E. North, Claes Ohlsson, Ken K. Ong, Inga Prokopenko, J. Brent Richards, Eric E. Schadt, Tim D. Spector, Elisabeth Widén, Cristen J. Willer, Jian Yang, Erik Ingelsson, Karen L. Mohlke, Joel N. Hirschhorn, John Andrew Pospisilik, M. Carola Zillikens, Cecilia Lindgren, Tuomas Oskari Kilpelaïnen, Ruth J.F. Loos

Research output: Contribution to journal › Article › peer-review

198 Scopus citations

Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (Po5108), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Original language	English (US)
Article number	10495
Journal	Nature communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms10495
State	Published - Feb 1 2016

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
General
Physics and Astronomy(all)

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10.1038/ncomms10495

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Lu, Y., Day, F. R., Gustafsson, S., Buchkovich, M. L., Na, J., Bataille, V., Cousminer, D. L., Dastani, Z., Drong, A. W., Esko, T., Evans, D. M., Falchi, M., Feitosa, M. F., Ferreira, T., Hedman, Å. K., Haring, R., Hysi, P. G., Iles, M. M., Justice, A. E., ... Loos, R. J. F. (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature communications, 7, [10495]. https://doi.org/10.1038/ncomms10495

Lu, Y, Day, FR, Gustafsson, S, Buchkovich, ML, Na, J, Bataille, V, Cousminer, DL, Dastani, Z, Drong, AW, Esko, T, Evans, DM, Falchi, M, Feitosa, MF, Ferreira, T, Hedman, ÅK, Haring, R, Hysi, PG, Iles, MM, Justice, AE, Kanoni, S, Lagou, V, Li, R, Li, X, Locke, A, Lu, C, Mägi, R, Perry, JRB, Pers, TH, Qi, Q, Sanna, M, Schmidt, EM, Scott, WR, Shungin, D, Teumer, A, Vinkhuyzen, AAE, Walker, RW, Westra, HJ, Zhang, M, Zhang, W, Zhao, JH, Zhu, Z, Afzal, U, Ahluwalia, TS, Bakker, SJL, Bellis, C, Bonnefond, A, Borodulin, K, Buchman, AS, Cederholm, T, Choh, AC, Choi, HJ, Curran, JE, De Groot, LCPGM, De Jager, PL, Dhonukshe-Rutten, RAM, Enneman, AW, Eury, E, Evans, DS, Forsen, T, Friedrich, N, Fumeron, F, Garcia, ME, Gärtner, S, Han, BG, Havulinna, AS, Hayward, C, Hernandez, D, Hillege, H, Ittermann, T, Kent, JW, Kolcic, I, Laatikainen, T, Lahti, J, Leach, IM, Lee, CG, Lee, JY, Liu, T, Liu, Y, Lobbens, S, Loh, M, Lyytikaïnen, LP, Medina-Gomez, C, Michaëlsson, K, Nalls, MA, Nielson, CM, Oozageer, L, Pascoe, L, Paternoster, L, Polašek, O, Ripatti, S, Sarzynski, MA, Shin, CS, Naranäiä, NS, Spira, D, Srikanth, P, Steinhagen-Thiessen, E, Sung, YJ, Swart, KMA, Taittonen, L, Tanaka, T, Tikkanen, E, Van Der Velde, N, Van Schoor, NM, Verweij, N, Wright, AF, Yu, L, Zmuda, JM, Eklund, N, Forrester, T, Grarup, N, Jackson, AU, Kristiansson, K, Kuulasmaa, T, Kuusisto, J, Lichtner, P, Luan, J, Mahajan, A, Männistö, S, Palmer, CD, Ried, JS, Scott, RA, Stancáková, A, Wagner, PJ, Demirkan, A, Döring, A, Gudnason, V, Kiel, DP, Kühnel, B, Mangino, M, McKnight, B, Menni, C, O'Connell, JR, Oostra, BA, Shuldiner, AR, Song, K, Vandenput, L, Van Duijn, CM, Vollenweider, P, White, CC, Boehnke, M, Boettcher, Y, Cooper, RS, Forouhi, NG, Gieger, C, Grallert, H, Hingorani, A, Jørgensen, T, Jousilahti, P, Kivimaki, M, Kumari, M, Laakso, M, Langenberg, C, Linneberg, A, Luke, A, McKenzie, CA, Palotie, A, Pedersen, O, Peters, A, Strauch, K, Tayo, BO, Wareham, NJ, Bennett, DA, Bertram, L, Blangero, J, Blüher, M, Bouchard, C, Campbell, H, Cho, NH, Cummings, SR, Czerwinski, SA, Demuth, I, Eckardt, R, Eriksson, JG, Ferrucci, L, Franco, OH, Froguel, P, Gansevoort, RT, Hansen, T, Harris, TB, Hastie, N, Heliövaara, M, Hofman, A, Jordan, JM, Jula, A, Kähönen, M, Kajantie, E, Knekt, PB, Koskinen, S, Kovacs, P, Lehtimäki, T, Lind, L, Liu, Y, Orwoll, ES, Osmond, C, Perola, M, Pérusse, L, Raitakari, OT, Rankinen, T, Rao, DC, Rice, TK, Rivadeneira, F, Rudan, I, Salomaa, V, Sørensen, TIA, Stumvoll, M, Tönjes, A, Towne, B, Tranah, GJ, Tremblay, A, Uitterlinden, AG, Van Der Harst, P, Vartiainen, E, Viikari, JS, Vitart, V, Vohl, MC, Völzke, H, Walker, M, Wallaschofski, H, Wild, S, Wilson, JF, Yengo, L, Bishop, DT, Borecki, IB, Chambers, JC, Cupples, LA, Dehghan, A, Deloukas, P, Fatemifar, G, Fox, C, Furey, TS, Franke, L, Han, J, Hunter, DJ, Karjalainen, J, Karpe, F, Kaplan, RC, Kooner, JS, McCarthy, MI, Murabito, JM, Morris, AP, Bishop, JAN, North, KE, Ohlsson, C, Ong, KK, Prokopenko, I, Richards, JB, Schadt, EE, Spector, TD, Widén, E, Willer, CJ, Yang, J, Ingelsson, E, Mohlke, KL, Hirschhorn, JN, Pospisilik, JA, Zillikens, MC, Lindgren, C, Kilpelaïnen, TO & Loos, RJF 2016, 'New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk', Nature communications, vol. 7, 10495. https://doi.org/10.1038/ncomms10495

@article{657cb026fad9480ba2087bd88d65b534,

title = "New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk",

abstract = "To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (Po5108), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.",

author = "Yingchang Lu and Day, {Felix R.} and Stefan Gustafsson and Buchkovich, {Martin L.} and Jianbo Na and Veronique Bataille and Cousminer, {Diana L.} and Zari Dastani and Drong, {Alexander W.} and To{\~n}u Esko and Evans, {David M.} and Mario Falchi and Feitosa, {Mary F.} and Teresa Ferreira and Hedman, {{\AA}sa K.} and Robin Haring and Hysi, {Pirro G.} and Iles, {Mark M.} and Justice, {Anne E.} and Stavroula Kanoni and Vasiliki Lagou and Rui Li and Xin Li and Adam Locke and Chen Lu and Reedik M{\"a}gi and Perry, {John R.B.} and Pers, {Tune H.} and Qibin Qi and Marianna Sanna and Schmidt, {Ellen M.} and Scott, {William R.} and Dmitry Shungin and Alexander Teumer and Vinkhuyzen, {Anna A.E.} and Walker, {Ryan W.} and Westra, {Harm Jan} and Mingfeng Zhang and Weihua Zhang and Zhao, {Jing Hua} and Zhihong Zhu and Uzma Afzal and Ahluwalia, {Tarunveer Singh} and Bakker, {Stephan J.L.} and Claire Bellis and Am{\'e}lie Bonnefond and Katja Borodulin and Buchman, {Aron S.} and Tommy Cederholm and Choh, {Audrey C.} and Choi, {Hyung Jin} and Curran, {Joanne E.} and {De Groot}, {Lisette C.P.G.M.} and {De Jager}, {Philip L.} and Dhonukshe-Rutten, {Rosalie A.M.} and Enneman, {Anke W.} and Elodie Eury and Evans, {Daniel S.} and Tom Forsen and Nele Friedrich and Fr{\'e}d{\'e}ric Fumeron and Garcia, {Melissa E.} and Simone G{\"a}rtner and Han, {Bok Ghee} and Havulinna, {Aki S.} and Caroline Hayward and Dena Hernandez and Hans Hillege and Till Ittermann and Kent, {Jack W.} and Ivana Kolcic and Tiina Laatikainen and Jari Lahti and Leach, {Irene Mateo} and Lee, {Christine G.} and Lee, {Jong Young} and Tian Liu and Youfang Liu and St{\'e}phane Lobbens and Marie Loh and Lyytika{\"i}nen, {Leo Pekka} and Carolina Medina-Gomez and Karl Micha{\"e}lsson and Nalls, {Mike A.} and Nielson, {Carrie M.} and Laticia Oozageer and Laura Pascoe and Lavinia Paternoster and Ozren Pola{\v s}ek and Samuli Ripatti and Sarzynski, {Mark A.} and Shin, {Chan Soo} and Naran{\"a}i{\"a}, {Nina Smolej} and Dominik Spira and Priya Srikanth and Elisabeth Steinhagen-Thiessen and Sung, {Yun Ju} and Swart, {Karin M.A.} and Leena Taittonen and Toshiko Tanaka and Emmi Tikkanen and {Van Der Velde}, Nathalie and {Van Schoor}, {Natasja M.} and Niek Verweij and Wright, {Alan F.} and Lei Yu and Zmuda, {Joseph M.} and Niina Eklund and Terrence Forrester and Niels Grarup and Jackson, {Anne U.} and Kati Kristiansson and Teemu Kuulasmaa and Johanna Kuusisto and Peter Lichtner and Jian'an Luan and Anubha Mahajan and Satu M{\"a}nnist{\"o} and Palmer, {Cameron D.} and Ried, {Janina S.} and Scott, {Robert A.} and Alena Stanc{\'a}kov{\'a} and Wagner, {Peter J.} and Ayse Demirkan and Angela D{\"o}ring and Vilmundur Gudnason and Kiel, {Douglas P.} and Brigitte K{\"u}hnel and Massimo Mangino and Barbara McKnight and Cristina Menni and O'Connell, {Jeffrey R.} and Oostra, {Ben A.} and Shuldiner, {Alan R.} and Kijoung Song and Liesbeth Vandenput and {Van Duijn}, {Cornelia M.} and Peter Vollenweider and White, {Charles C.} and Michael Boehnke and Yvonne Boettcher and Cooper, {Richard S.} and Forouhi, {Nita G.} and Christian Gieger and Harald Grallert and Aroon Hingorani and Torben J{\o}rgensen and Pekka Jousilahti and Mika Kivimaki and Meena Kumari and Markku Laakso and Claudia Langenberg and Allan Linneberg and Amy Luke and McKenzie, {Colin A.} and Aarno Palotie and Oluf Pedersen and Annette Peters and Konstantin Strauch and Tayo, {Bamidele O.} and Wareham, {Nicholas J.} and Bennett, {David A.} and Lars Bertram and John Blangero and Matthias Bl{\"u}her and Claude Bouchard and Harry Campbell and Cho, {Nam H.} and Cummings, {Steven R.} and Czerwinski, {Stefan A.} and Ilja Demuth and Rahel Eckardt and Eriksson, {Johan G.} and Luigi Ferrucci and Franco, {Oscar H.} and Philippe Froguel and Gansevoort, {Ron T.} and Torben Hansen and Harris, {Tamara B.} and Nicholas Hastie and Markku Heli{\"o}vaara and Albert Hofman and Jordan, {Joanne M.} and Antti Jula and Mika K{\"a}h{\"o}nen and Eero Kajantie and Knekt, {Paul B.} and Seppo Koskinen and Peter Kovacs and Terho Lehtim{\"a}ki and Lars Lind and Yongmei Liu and Orwoll, {Eric S.} and Clive Osmond and Markus Perola and Louis P{\'e}russe and Raitakari, {Olli T.} and Tuomo Rankinen and Rao, {D. C.} and Rice, {Treva K.} and Fernando Rivadeneira and Igor Rudan and Veikko Salomaa and S{\o}rensen, {Thorkild I.A.} and Michael Stumvoll and Anke T{\"o}njes and Bradford Towne and Tranah, {Gregory J.} and Angelo Tremblay and Uitterlinden, {Andr{\'e} G.} and {Van Der Harst}, Pim and Erkki Vartiainen and Viikari, {Jorma S.} and Veronique Vitart and Vohl, {Marie Claude} and Henry V{\"o}lzke and Mark Walker and Henri Wallaschofski and Sarah Wild and Wilson, {James F.} and Lo{\"i}c Yengo and Bishop, {D. Timothy} and Borecki, {Ingrid B.} and Chambers, {John C.} and Cupples, {L. Adrienne} and Abbas Dehghan and Panos Deloukas and Ghazaleh Fatemifar and Caroline Fox and Furey, {Terrence S.} and Lude Franke and Jiali Han and Hunter, {David J.} and Juha Karjalainen and Fredrik Karpe and Kaplan, {Robert C.} and Kooner, {Jaspal S.} and McCarthy, {Mark I.} and Murabito, {Joanne M.} and Morris, {Andrew P.} and Bishop, {Julia A.N.} and North, {Kari E.} and Claes Ohlsson and Ong, {Ken K.} and Inga Prokopenko and Richards, {J. Brent} and Schadt, {Eric E.} and Spector, {Tim D.} and Elisabeth Wid{\'e}n and Willer, {Cristen J.} and Jian Yang and Erik Ingelsson and Mohlke, {Karen L.} and Hirschhorn, {Joel N.} and Pospisilik, {John Andrew} and Zillikens, {M. Carola} and Cecilia Lindgren and Kilpela{\"i}nen, {Tuomas Oskari} and Loos, {Ruth J.F.}",

note = "Funding Information: A full list of acknowledgements can be found in the Supplementary Notes. This work was supported by the following: Aase and Ejner Danielsens Foundation; Academy of Finland; Agency for Health Care Policy Research; Ahokas Foundation; ALFEDIAM; ALK-Abell{\'o} A/S (H{\o}rsholm, Denmark); Althingi (the Icelandic Parliament); ANR ({\textquoteleft}Agence Nationale de la 359 Recherche{\textquoteright}); American Heart Association; Ardix Medical; Arthritis Research UK; Association Diab{\'e}te Risque Vasculaire, the F{\'e}d{\'e}ration Francaise de Cardiologie; AstraZeneca; Australian Research Council; Bayer Diagnostics; BBSRC; Becton Dickinson; BMBF (DEEP); Boehringer Ingelheim Foundation; Boston University School of Medicine; British Heart Foundation; British Skin Foundation; Canadian Institutes of Health Research; Cancer Research UK; Cardionics; Centers for Disease Control and Prevention/Association of Schools of Public Health; Chief Scientist Office of the Scottish Government; Cohortes Sant{\'e} TGIR; CMSB; CPER ({\textquoteleft}Contrat de Projets {\'E}tat-R{\'e}gion{\textquoteright}); Danish Agency for Science, Technology and Innovation; Danish Council for Independent Research; Danish Medical Research Council; Department of Health, UK; Deutsche Forschungsgemeinschaft; Deutshe Forschungsgemeinschaft (SFB992); DHFD (Diabetes Hilfs- und Forschungsfonds Deutschland); Diabetes UK; Dutch Dairy Association (NZO); Dutch Kidney Foundation; Dutch Inter University Cardiology Institute Netherlands (ICIN); Emil Aaltonen Foundation; ENGAGE consortium; Food Standards Agency, UK; Erasmus Medical Center; Erasmus University; Estonian Government; European Commission; European Community{\textquoteright}s Seventh Framework Programme; European Research Council; European Research Council (ERC-StG- 281641); European Union framework program 6 EUROSPAN project; European Union; European Union (EU_FP7_NoE {\textquoteleft}Epigenesys{\textquoteright}); Faculty of Biology and Medicine of Lausanne; Federal State of Mecklenburg-West Pomerania; Federal Ministry of Education and Research (German Obesity Biomaterial Bank); Finnish Cardiovascular Research Foundation; Finnish Centre for Pensions; Finnish Cultural Foundation; Finnish Diabetes Research Foundation; Finnish Diabetes Research Society; Finnish Foundation for Cardiovascular Research; Finnish Foundation for Pediatric Research; Finnish Special Governmental Subsidy for Health Sciences; Finska L{\"a}kares{\"a}llskapet; Folkh{\"a}lsan Research Foundation; German Bundesministerium fuer Forschung und Technology; German Diabetes Association; German Federal Ministry of Education and Research (Bundesministerium f{\"u}r Bildung und Forschung, BMBF); German Research Council; GlaxoSmithKline; G{\"o}ran Gustafsson Foundation; Health and Safety Executive, UK; Helmholtz Zentrum Mu¨nchen—German Research Center for Environmental Health; Hjartavernd (the Icelandic Heart Association); Illinois Department of Public Health; INSERM (R{\'e}seaux en Sant{\'e} Publique, Interactions entre les d{\'e}terminants de la sant{\'e}); Integrated Research and Treatment Centre (IFB); Juho Vainio Foundation; John D and Catherine T MacArthur Foundation Research Networks; John W. Barton Sr Chair in Genetics and Nutrition; Kompetenznetz Adipositas; King{\textquoteright}s College London; Knut och Alice Wallenberg Foundation; Kuopio, Tampere and Turku University Hospital Medical Funds; Kuopio University Hospital; La Fondation de France; Li Ka Shing Foundation; Liv och Ha¨lsa; Local Government Pensions Institution (KEVA); Ludwig-Maximilians- Universita¨t; Lundbeck Foundation; Lundberg Foundation; Max-Planck Institute; Medical Research Council, UK; MEKOS Laboratories Denmark; Merck Sant{\'e}; Ministry for Health, Welfare and Sports, The Netherlands; Ministry of Cultural Affairs and Social Ministry of the Federal State of Mecklenburg-West Pomerania; Ministry of Economic Affairs, Agriculture and Innovation, The Netherlands; Ministry of Education, Culture and Science, The Netherlands; Ministry of Science, Education and Sport of the Republic of Croatia; MRC Centre for Causal Analyses in Translational Epidemiology (MRC CAiTE); MRC-GlaxoSmithKline; MRC Human Genetics Unit; Munich Center of Health Sciences (MC Health); Municipality of Rotterdam; National Center for Advancing Translational Sciences, CTSI; National Center for Research Resources (NCRR); National Genome Research Institute, Korean Center for Disease Control and Prevention; National Heart Lung and Blood Institute (NHLBI); National Heart, Lung and Blood Institute{\textquoteright}s Framingham Heart Study; National Institute for Health and Welfare (THL); National Institute for Health Research (NIHR); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); National Institutes of Health; National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC); National Institute of Neurological Disorders and Stroke (NINDS); National Institute on Aging (NIA); Netherlands Consortium Healthy Ageing (NCHA); Netherlands Genomics Initiative (NGI); Netherlands Heart Foundation; Netherlands Organisation for Scientific Research (NWO); Netherlands Organization for the Health Research and Development (ZonMw); Novo Nordisk; Novo Nordisk Foundation; ONIVINS; Orion-Farmos Research Foundation; Paavo Nurmi Foundation; Pierre Fabre; Research Centre for Prevention and Health, the Capital Region of Denmark; Research Institute for Diseases in the Elderly (RIDE); Research into Ageing, UK; Roche; Royal Swedish Academy of Science; Russian Foundation for Basic Research; Sanger Institute; Samfundet Folkh{\"a}lsan; SFD ({\textquoteleft}Soci{\'e}te Francophone du 358 Diab{\'e}t{\'e}); Siemens Healthcare; Signe and Ane Gyllenberg Foundation; Sigrid Jus{\'e}lius Foundation; Social Insurance Institution of Finland (KELA); State of Bavaria; Stroke Association, UK; Swedish Diabetes Foundation; Swedish Foundation for Strategic Research; Swedish Heart-Lung Foundation; Swedish Research Council; Swedish Research Council for Infrastructures; Swiss National Science Foundation; Sylvia & Charles Viertel Charitable Foundation; Tampere Tuberculosis Foundation; Timber Merchant Vilhelm Bangs Foundation; Topcon; Torsten and Ragnar So¨derberg{\textquoteright}s Foundation; Translational Genomics Research Institute; Unilever UK; University Cancer Research Fund at UNC Chapel Hill; University of Eastern Finland; University of Maryland General Clinical Research Center; Uppsala University; Uppsala University Hospital; USDA National Institute of Food and Agriculture; VA Clinical Science Research and Development; Velux Foundation; VU University Medical Center; Wageningen University; Wellcome Trust.",

year = "2016",

month = feb,

day = "1",

doi = "10.1038/ncomms10495",

language = "English (US)",

volume = "7",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

AU - Lu, Yingchang

AU - Day, Felix R.

AU - Gustafsson, Stefan

AU - Buchkovich, Martin L.

AU - Na, Jianbo

AU - Bataille, Veronique

AU - Cousminer, Diana L.

AU - Dastani, Zari

AU - Drong, Alexander W.

AU - Esko, Toñu

AU - Evans, David M.

AU - Falchi, Mario

AU - Feitosa, Mary F.

AU - Ferreira, Teresa

AU - Hedman, Åsa K.

AU - Haring, Robin

AU - Hysi, Pirro G.

AU - Iles, Mark M.

AU - Justice, Anne E.

AU - Kanoni, Stavroula

AU - Lagou, Vasiliki

AU - Li, Rui

AU - Li, Xin

AU - Locke, Adam

AU - Lu, Chen

AU - Mägi, Reedik

AU - Perry, John R.B.

AU - Pers, Tune H.

AU - Qi, Qibin

AU - Sanna, Marianna

AU - Schmidt, Ellen M.

AU - Scott, William R.

AU - Shungin, Dmitry

AU - Teumer, Alexander

AU - Vinkhuyzen, Anna A.E.

AU - Walker, Ryan W.

AU - Westra, Harm Jan

AU - Zhang, Mingfeng

AU - Zhang, Weihua

AU - Zhao, Jing Hua

AU - Zhu, Zhihong

AU - Afzal, Uzma

AU - Ahluwalia, Tarunveer Singh

AU - Bakker, Stephan J.L.

AU - Bellis, Claire

AU - Bonnefond, Amélie

AU - Borodulin, Katja

AU - Buchman, Aron S.

AU - Cederholm, Tommy

AU - Choh, Audrey C.

AU - Choi, Hyung Jin

AU - Curran, Joanne E.

AU - De Groot, Lisette C.P.G.M.

AU - De Jager, Philip L.

AU - Dhonukshe-Rutten, Rosalie A.M.

AU - Enneman, Anke W.

AU - Eury, Elodie

AU - Evans, Daniel S.

AU - Forsen, Tom

AU - Friedrich, Nele

AU - Fumeron, Frédéric

AU - Garcia, Melissa E.

AU - Gärtner, Simone

AU - Han, Bok Ghee

AU - Havulinna, Aki S.

AU - Hayward, Caroline

AU - Hernandez, Dena

AU - Hillege, Hans

AU - Ittermann, Till

AU - Kent, Jack W.

AU - Kolcic, Ivana

AU - Laatikainen, Tiina

AU - Lahti, Jari

AU - Leach, Irene Mateo

AU - Lee, Christine G.

AU - Lee, Jong Young

AU - Liu, Tian

AU - Liu, Youfang

AU - Lobbens, Stéphane

AU - Loh, Marie

AU - Lyytikaïnen, Leo Pekka

AU - Medina-Gomez, Carolina

AU - Michaëlsson, Karl

AU - Nalls, Mike A.

AU - Nielson, Carrie M.

AU - Oozageer, Laticia

AU - Pascoe, Laura

AU - Paternoster, Lavinia

AU - Polašek, Ozren

AU - Ripatti, Samuli

AU - Sarzynski, Mark A.

AU - Shin, Chan Soo

AU - Naranäiä, Nina Smolej

AU - Spira, Dominik

AU - Srikanth, Priya

AU - Steinhagen-Thiessen, Elisabeth

AU - Sung, Yun Ju

AU - Swart, Karin M.A.

AU - Taittonen, Leena

AU - Tanaka, Toshiko

AU - Tikkanen, Emmi

AU - Van Der Velde, Nathalie

AU - Van Schoor, Natasja M.

AU - Verweij, Niek

AU - Wright, Alan F.

AU - Yu, Lei

AU - Zmuda, Joseph M.

AU - Eklund, Niina

AU - Forrester, Terrence

AU - Grarup, Niels

AU - Jackson, Anne U.

AU - Kristiansson, Kati

AU - Kuulasmaa, Teemu

AU - Kuusisto, Johanna

AU - Lichtner, Peter

AU - Luan, Jian'an

AU - Mahajan, Anubha

AU - Männistö, Satu

AU - Palmer, Cameron D.

AU - Ried, Janina S.

AU - Scott, Robert A.

AU - Stancáková, Alena

AU - Wagner, Peter J.

AU - Demirkan, Ayse

AU - Döring, Angela

AU - Gudnason, Vilmundur

AU - Kiel, Douglas P.

AU - Kühnel, Brigitte

AU - Mangino, Massimo

AU - McKnight, Barbara

AU - Menni, Cristina

AU - O'Connell, Jeffrey R.

AU - Oostra, Ben A.

AU - Shuldiner, Alan R.

AU - Song, Kijoung

AU - Vandenput, Liesbeth

AU - Van Duijn, Cornelia M.

AU - Vollenweider, Peter

AU - White, Charles C.

AU - Boehnke, Michael

AU - Boettcher, Yvonne

AU - Cooper, Richard S.

AU - Forouhi, Nita G.

AU - Gieger, Christian

AU - Grallert, Harald

AU - Hingorani, Aroon

AU - Jørgensen, Torben

AU - Jousilahti, Pekka

AU - Kivimaki, Mika

AU - Kumari, Meena

AU - Laakso, Markku

AU - Langenberg, Claudia

AU - Linneberg, Allan

AU - Luke, Amy

AU - McKenzie, Colin A.

AU - Palotie, Aarno

AU - Pedersen, Oluf

AU - Peters, Annette

AU - Strauch, Konstantin

AU - Tayo, Bamidele O.

AU - Wareham, Nicholas J.

AU - Bennett, David A.

AU - Bertram, Lars

AU - Blangero, John

AU - Blüher, Matthias

AU - Bouchard, Claude

AU - Campbell, Harry

AU - Cho, Nam H.

AU - Cummings, Steven R.

AU - Czerwinski, Stefan A.

AU - Demuth, Ilja

AU - Eckardt, Rahel

AU - Eriksson, Johan G.

AU - Ferrucci, Luigi

AU - Franco, Oscar H.

AU - Froguel, Philippe

AU - Gansevoort, Ron T.

AU - Hansen, Torben

AU - Harris, Tamara B.

AU - Hastie, Nicholas

AU - Heliövaara, Markku

AU - Hofman, Albert

AU - Jordan, Joanne M.

AU - Jula, Antti

AU - Kähönen, Mika

AU - Kajantie, Eero

AU - Knekt, Paul B.

AU - Koskinen, Seppo

AU - Kovacs, Peter

AU - Lehtimäki, Terho

AU - Lind, Lars

AU - Liu, Yongmei

AU - Orwoll, Eric S.

AU - Osmond, Clive

AU - Perola, Markus

AU - Pérusse, Louis

AU - Raitakari, Olli T.

AU - Rankinen, Tuomo

AU - Rao, D. C.

AU - Rice, Treva K.

AU - Rivadeneira, Fernando

AU - Rudan, Igor

AU - Salomaa, Veikko

AU - Sørensen, Thorkild I.A.

AU - Stumvoll, Michael

AU - Tönjes, Anke

AU - Towne, Bradford

AU - Tranah, Gregory J.

AU - Tremblay, Angelo

AU - Uitterlinden, André G.

AU - Van Der Harst, Pim

AU - Vartiainen, Erkki

AU - Viikari, Jorma S.

AU - Vitart, Veronique

AU - Vohl, Marie Claude

AU - Völzke, Henry

AU - Walker, Mark

AU - Wallaschofski, Henri

AU - Wild, Sarah

AU - Wilson, James F.

AU - Yengo, Loïc

AU - Bishop, D. Timothy

AU - Borecki, Ingrid B.

AU - Chambers, John C.

AU - Cupples, L. Adrienne

AU - Dehghan, Abbas

AU - Deloukas, Panos

AU - Fatemifar, Ghazaleh

AU - Fox, Caroline

AU - Furey, Terrence S.

AU - Franke, Lude

AU - Han, Jiali

AU - Hunter, David J.

AU - Karjalainen, Juha

AU - Karpe, Fredrik

AU - Kaplan, Robert C.

AU - Kooner, Jaspal S.

AU - McCarthy, Mark I.

AU - Murabito, Joanne M.

AU - Morris, Andrew P.

AU - Bishop, Julia A.N.

AU - North, Kari E.

AU - Ohlsson, Claes

AU - Ong, Ken K.

AU - Prokopenko, Inga

AU - Richards, J. Brent

AU - Schadt, Eric E.

AU - Spector, Tim D.

AU - Widén, Elisabeth

AU - Willer, Cristen J.

AU - Yang, Jian

AU - Ingelsson, Erik

AU - Mohlke, Karen L.

AU - Hirschhorn, Joel N.

AU - Pospisilik, John Andrew

AU - Zillikens, M. Carola

AU - Lindgren, Cecilia

AU - Kilpelaïnen, Tuomas Oskari

AU - Loos, Ruth J.F.

N1 - Funding Information: A full list of acknowledgements can be found in the Supplementary Notes. This work was supported by the following: Aase and Ejner Danielsens Foundation; Academy of Finland; Agency for Health Care Policy Research; Ahokas Foundation; ALFEDIAM; ALK-Abelló A/S (Hørsholm, Denmark); Althingi (the Icelandic Parliament); ANR (‘Agence Nationale de la 359 Recherche’); American Heart Association; Ardix Medical; Arthritis Research UK; Association Diabéte Risque Vasculaire, the Fédération Francaise de Cardiologie; AstraZeneca; Australian Research Council; Bayer Diagnostics; BBSRC; Becton Dickinson; BMBF (DEEP); Boehringer Ingelheim Foundation; Boston University School of Medicine; British Heart Foundation; British Skin Foundation; Canadian Institutes of Health Research; Cancer Research UK; Cardionics; Centers for Disease Control and Prevention/Association of Schools of Public Health; Chief Scientist Office of the Scottish Government; Cohortes Santé TGIR; CMSB; CPER (‘Contrat de Projets État-Région’); Danish Agency for Science, Technology and Innovation; Danish Council for Independent Research; Danish Medical Research Council; Department of Health, UK; Deutsche Forschungsgemeinschaft; Deutshe Forschungsgemeinschaft (SFB992); DHFD (Diabetes Hilfs- und Forschungsfonds Deutschland); Diabetes UK; Dutch Dairy Association (NZO); Dutch Kidney Foundation; Dutch Inter University Cardiology Institute Netherlands (ICIN); Emil Aaltonen Foundation; ENGAGE consortium; Food Standards Agency, UK; Erasmus Medical Center; Erasmus University; Estonian Government; European Commission; European Community’s Seventh Framework Programme; European Research Council; European Research Council (ERC-StG- 281641); European Union framework program 6 EUROSPAN project; European Union; European Union (EU_FP7_NoE ‘Epigenesys’); Faculty of Biology and Medicine of Lausanne; Federal State of Mecklenburg-West Pomerania; Federal Ministry of Education and Research (German Obesity Biomaterial Bank); Finnish Cardiovascular Research Foundation; Finnish Centre for Pensions; Finnish Cultural Foundation; Finnish Diabetes Research Foundation; Finnish Diabetes Research Society; Finnish Foundation for Cardiovascular Research; Finnish Foundation for Pediatric Research; Finnish Special Governmental Subsidy for Health Sciences; Finska Läkaresällskapet; Folkhälsan Research Foundation; German Bundesministerium fuer Forschung und Technology; German Diabetes Association; German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF); German Research Council; GlaxoSmithKline; Göran Gustafsson Foundation; Health and Safety Executive, UK; Helmholtz Zentrum Mu¨nchen—German Research Center for Environmental Health; Hjartavernd (the Icelandic Heart Association); Illinois Department of Public Health; INSERM (Réseaux en Santé Publique, Interactions entre les déterminants de la santé); Integrated Research and Treatment Centre (IFB); Juho Vainio Foundation; John D and Catherine T MacArthur Foundation Research Networks; John W. Barton Sr Chair in Genetics and Nutrition; Kompetenznetz Adipositas; King’s College London; Knut och Alice Wallenberg Foundation; Kuopio, Tampere and Turku University Hospital Medical Funds; Kuopio University Hospital; La Fondation de France; Li Ka Shing Foundation; Liv och Ha¨lsa; Local Government Pensions Institution (KEVA); Ludwig-Maximilians- Universita¨t; Lundbeck Foundation; Lundberg Foundation; Max-Planck Institute; Medical Research Council, UK; MEKOS Laboratories Denmark; Merck Santé; Ministry for Health, Welfare and Sports, The Netherlands; Ministry of Cultural Affairs and Social Ministry of the Federal State of Mecklenburg-West Pomerania; Ministry of Economic Affairs, Agriculture and Innovation, The Netherlands; Ministry of Education, Culture and Science, The Netherlands; Ministry of Science, Education and Sport of the Republic of Croatia; MRC Centre for Causal Analyses in Translational Epidemiology (MRC CAiTE); MRC-GlaxoSmithKline; MRC Human Genetics Unit; Munich Center of Health Sciences (MC Health); Municipality of Rotterdam; National Center for Advancing Translational Sciences, CTSI; National Center for Research Resources (NCRR); National Genome Research Institute, Korean Center for Disease Control and Prevention; National Heart Lung and Blood Institute (NHLBI); National Heart, Lung and Blood Institute’s Framingham Heart Study; National Institute for Health and Welfare (THL); National Institute for Health Research (NIHR); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); National Institutes of Health; National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC); National Institute of Neurological Disorders and Stroke (NINDS); National Institute on Aging (NIA); Netherlands Consortium Healthy Ageing (NCHA); Netherlands Genomics Initiative (NGI); Netherlands Heart Foundation; Netherlands Organisation for Scientific Research (NWO); Netherlands Organization for the Health Research and Development (ZonMw); Novo Nordisk; Novo Nordisk Foundation; ONIVINS; Orion-Farmos Research Foundation; Paavo Nurmi Foundation; Pierre Fabre; Research Centre for Prevention and Health, the Capital Region of Denmark; Research Institute for Diseases in the Elderly (RIDE); Research into Ageing, UK; Roche; Royal Swedish Academy of Science; Russian Foundation for Basic Research; Sanger Institute; Samfundet Folkhälsan; SFD (‘Sociéte Francophone du 358 Diabété); Siemens Healthcare; Signe and Ane Gyllenberg Foundation; Sigrid Jusélius Foundation; Social Insurance Institution of Finland (KELA); State of Bavaria; Stroke Association, UK; Swedish Diabetes Foundation; Swedish Foundation for Strategic Research; Swedish Heart-Lung Foundation; Swedish Research Council; Swedish Research Council for Infrastructures; Swiss National Science Foundation; Sylvia & Charles Viertel Charitable Foundation; Tampere Tuberculosis Foundation; Timber Merchant Vilhelm Bangs Foundation; Topcon; Torsten and Ragnar So¨derberg’s Foundation; Translational Genomics Research Institute; Unilever UK; University Cancer Research Fund at UNC Chapel Hill; University of Eastern Finland; University of Maryland General Clinical Research Center; Uppsala University; Uppsala University Hospital; USDA National Institute of Food and Agriculture; VA Clinical Science Research and Development; Velux Foundation; VU University Medical Center; Wageningen University; Wellcome Trust.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (Po5108), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

AB - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (Po5108), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

UR - http://www.scopus.com/inward/record.url?scp=84965156172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84965156172&partnerID=8YFLogxK

U2 - 10.1038/ncomms10495

DO - 10.1038/ncomms10495

M3 - Article

C2 - 26833246

AN - SCOPUS:84965156172

SN - 2041-1723

VL - 7

JO - Nature Communications

JF - Nature Communications

M1 - 10495

ER -

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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