TY - JOUR
T1 - New Names for Old Tumors
AU - Wong, Mary
AU - Waters, Kevin M.
AU - Guindi, Maha
AU - Larson, Brent K.
N1 - Publisher Copyright:
© 2020 American Society for Clinical Pathology, 2020. All rights reserved.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Objectives: Previous studies described "clear cell"hepatocellular carcinoma (HCC), although definitions have varied. New clear cell subtypes of HCC have been proposed, including chromophobe (C-HCC), steatohepatitic (SH-HCC), and steatotic (S-HCC), and this study assessed the utility and clinical-pathologic profile of these subtypes. Methods: Current histologic definitions, including 3 separate proposed definitions for SH-HCC, were applied to tumors previously characterized as clear cell HCC. Histologic and clinical variables were analyzed. Results: Of 66 HCCs, 51 (77%) were classified using modern definitions, including 34 SH-HCCs, 15 S-HCCs, and 2 C-HCCs. Compared with the most permissive SH-HCC definition, the other 2 definitions designated 30 and 25 SH-HCCs (-12% and-26% cases, respectively). Unsurprisingly, S-HCC and SH-HCC were associated with steatotic clear cells (P <. 0001). S-HCC was also more typically early type and low grade (P =. 0017). The remaining unclassified clear cell HCCs were associated with flocculent (rather than steatotic or optically clear) cytoplasm (P <. 0001) but otherwise demonstrated no discrete clinical-pathologic profile. Conclusions: Current definitions could be used to reclassify the majority of "clear cell"HCCs. The subtypes are significantly correlated with a few variables, suggesting valid differences of the subtypes, although additional study is warranted, particularly to standardize the definition of SH-HCC.
AB - Objectives: Previous studies described "clear cell"hepatocellular carcinoma (HCC), although definitions have varied. New clear cell subtypes of HCC have been proposed, including chromophobe (C-HCC), steatohepatitic (SH-HCC), and steatotic (S-HCC), and this study assessed the utility and clinical-pathologic profile of these subtypes. Methods: Current histologic definitions, including 3 separate proposed definitions for SH-HCC, were applied to tumors previously characterized as clear cell HCC. Histologic and clinical variables were analyzed. Results: Of 66 HCCs, 51 (77%) were classified using modern definitions, including 34 SH-HCCs, 15 S-HCCs, and 2 C-HCCs. Compared with the most permissive SH-HCC definition, the other 2 definitions designated 30 and 25 SH-HCCs (-12% and-26% cases, respectively). Unsurprisingly, S-HCC and SH-HCC were associated with steatotic clear cells (P <. 0001). S-HCC was also more typically early type and low grade (P =. 0017). The remaining unclassified clear cell HCCs were associated with flocculent (rather than steatotic or optically clear) cytoplasm (P <. 0001) but otherwise demonstrated no discrete clinical-pathologic profile. Conclusions: Current definitions could be used to reclassify the majority of "clear cell"HCCs. The subtypes are significantly correlated with a few variables, suggesting valid differences of the subtypes, although additional study is warranted, particularly to standardize the definition of SH-HCC.
KW - Hepatocellular carcinoma
KW - atty liver disease
KW - iver
KW - lear cell
KW - teatohepatitis
KW - teatosis
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U2 - 10.1093/ajcp/aqaa184
DO - 10.1093/ajcp/aqaa184
M3 - Article
C2 - 33258899
AN - SCOPUS:85105765323
SN - 0002-9173
VL - 155
SP - 698
EP - 710
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 5
ER -