Next-gen tools in cancer neuroscience

Vera Thiel; Debpali Sur; Caroline C. Picoli; Tamara McErlain; Katalina Couto; David J. Simon; Yuan Pan; Karen Olivia Dixon; Rajan P. Kulkarni; Sebastien Talbot; Alexander Birbrair

doi:10.1016/j.celrep.2025.116258

Next-gen tools in cancer neuroscience

Vera Thiel
, Debpali Sur
, Caroline C. Picoli
, Tamara McErlain
, Katalina Couto
, David J. Simon
, Yuan Pan
, Karen Olivia Dixon
, Rajan P. Kulkarni
, Sebastien Talbot
, Alexander Birbrair

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The emerging field of cancer neuroscience is rapidly evolving, driven by novel technologies and tools. These include advances in single-cell and spatial transcriptomics; genetic mouse models paired with automated high-throughput; and innovative optical electrophysiological approaches, optogenetics, chemogenetics, engineered viruses, and new methods for visualizing neuronal activity. Collectively, these technologies are revolutionizing how we investigate, manipulate, and characterize distinct components that contribute to the nervous system-cancer interface. In the present review, we discuss the key technologies that are closing the gap between oncology and neuroscience, highlighting the innovations that are propelling the cancer neuroscience field forward.

Original language	English (US)
Article number	116258
Journal	Cell Reports
Volume	44
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2025.116258
State	Published - Sep 23 2025

Keywords

CP: Cancer
CP: Neuroscience
cancer neuroscience
chemogenetics
imaging
optogenetics
transcriptomics
viral vectors

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2025.116258

Cite this

@article{5ddd2c3d510441d594cee147bafda6be,

title = "Next-gen tools in cancer neuroscience",

abstract = "The emerging field of cancer neuroscience is rapidly evolving, driven by novel technologies and tools. These include advances in single-cell and spatial transcriptomics; genetic mouse models paired with automated high-throughput; and innovative optical electrophysiological approaches, optogenetics, chemogenetics, engineered viruses, and new methods for visualizing neuronal activity. Collectively, these technologies are revolutionizing how we investigate, manipulate, and characterize distinct components that contribute to the nervous system-cancer interface. In the present review, we discuss the key technologies that are closing the gap between oncology and neuroscience, highlighting the innovations that are propelling the cancer neuroscience field forward.",

keywords = "CP: Cancer, CP: Neuroscience, cancer neuroscience, chemogenetics, imaging, optogenetics, transcriptomics, viral vectors",

author = "Vera Thiel and Debpali Sur and Picoli, \{Caroline C.\} and Tamara McErlain and Katalina Couto and Simon, \{David J.\} and Yuan Pan and Dixon, \{Karen Olivia\} and Kulkarni, \{Rajan P.\} and Sebastien Talbot and Alexander Birbrair",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s)",

year = "2025",

month = sep,

day = "23",

doi = "10.1016/j.celrep.2025.116258",

language = "English (US)",

volume = "44",

journal = "Cell Reports",

issn = "2639-1856",

publisher = "Elsevier BV",

number = "9",

}

TY - JOUR

T1 - Next-gen tools in cancer neuroscience

AU - Thiel, Vera

AU - Sur, Debpali

AU - Picoli, Caroline C.

AU - McErlain, Tamara

AU - Couto, Katalina

AU - Simon, David J.

AU - Pan, Yuan

AU - Dixon, Karen Olivia

AU - Kulkarni, Rajan P.

AU - Talbot, Sebastien

AU - Birbrair, Alexander

PY - 2025/9/23

Y1 - 2025/9/23

N2 - The emerging field of cancer neuroscience is rapidly evolving, driven by novel technologies and tools. These include advances in single-cell and spatial transcriptomics; genetic mouse models paired with automated high-throughput; and innovative optical electrophysiological approaches, optogenetics, chemogenetics, engineered viruses, and new methods for visualizing neuronal activity. Collectively, these technologies are revolutionizing how we investigate, manipulate, and characterize distinct components that contribute to the nervous system-cancer interface. In the present review, we discuss the key technologies that are closing the gap between oncology and neuroscience, highlighting the innovations that are propelling the cancer neuroscience field forward.

AB - The emerging field of cancer neuroscience is rapidly evolving, driven by novel technologies and tools. These include advances in single-cell and spatial transcriptomics; genetic mouse models paired with automated high-throughput; and innovative optical electrophysiological approaches, optogenetics, chemogenetics, engineered viruses, and new methods for visualizing neuronal activity. Collectively, these technologies are revolutionizing how we investigate, manipulate, and characterize distinct components that contribute to the nervous system-cancer interface. In the present review, we discuss the key technologies that are closing the gap between oncology and neuroscience, highlighting the innovations that are propelling the cancer neuroscience field forward.

KW - CP: Cancer

KW - CP: Neuroscience

KW - cancer neuroscience

KW - chemogenetics

KW - imaging

KW - optogenetics

KW - transcriptomics

KW - viral vectors

UR - https://www.scopus.com/pages/publications/105015324125

UR - https://www.scopus.com/pages/publications/105015324125#tab=citedBy

U2 - 10.1016/j.celrep.2025.116258

DO - 10.1016/j.celrep.2025.116258

M3 - Review article

C2 - 40934086

AN - SCOPUS:105015324125

SN - 2639-1856

VL - 44

JO - Cell Reports

JF - Cell Reports

IS - 9

M1 - 116258

ER -

Next-gen tools in cancer neuroscience

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this