NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review

William M. Oldham, Anna R. Hemnes, Micheala A. Aldred, John Barnard, Evan L. Brittain, Stephen Y. Chan, Feixiong Cheng, Michael H. Cho, Ankit A. Desai, Joe G.N. Garcia, Mark W. Geraci, Susan D. Ghiassian, Kathryn T. Hall, Evelyn M. Horn, Mohit Jain, Rachel S. Kelly, Jane A. Leopold, Sara Lindstrom, Brian D. Modena, William C. NicholsChristopher J. Rhodes, Wei Sun, Andrew J. Sweatt, Rebecca R. Vanderpool, Martin R. Wilkins, Beth Wilmot, Roham T. Zamanian, Joshua P. Fessel, Neil R. Aggarwal, Joseph Loscalzo, Lei Xiao

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


The National Heart, Lung, and Blood Institute and the Cardiovascular Medical Research and Education Fund held a workshop on the application of pulmonary vascular disease omics data to the understanding, prevention, and treatment of pulmonary vascular disease. Experts in pulmonary vascular disease, omics, and data analytics met to identify knowledge gaps and formulate ideas for future research priorities in pulmonary vascular disease in line with National Heart, Lung, and Blood Institute Strategic Vision goals. The group identified opportunities to develop analytic approaches to multiomic datasets, to identify molecular pathways in pulmonary vascular disease pathobiology, and to link novel phenotypes to meaningful clinical outcomes. The committee suggested support for interdisciplinary research teams to develop and validate analytic methods, a national effort to coordinate biosamples and data, a consortium of preclinical investigators to expedite target evaluation and drug development, longitudinal assessment of molecular biomarkers in clinical trials, and a task force to develop a master clinical trials protocol for pulmonary vascular disease.

Original languageEnglish (US)
Pages (from-to)2040-2052
Number of pages13
JournalJournal of the American College of Cardiology
Issue number16
StatePublished - Apr 27 2021


  • drug repurposing
  • integrative omics
  • master clinical trial protocol
  • precision medicine
  • pulmonary hypertension
  • systems biology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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