TY - JOUR
T1 - NLRs in immune privileged sites
AU - Rosenzweig, Holly L.
AU - Planck, Stephen
AU - Rosenbaum, James (Jim)
N1 - Funding Information:
Funding support : This work was made possible by the support from National Eye Institute at NIH (grants EY019020 (HLR) and EY019604 (JTR) ). Additional support was provided by the Stan and Madelle Rosenfeld Family Trust, the William and Mary Bauman Foundation, the William C. Kuzell Foundation, and Research to Prevent Blindness. HLR also receives support from the Research to Prevent Blindness and the American College of Rheumatology.
PY - 2011/8
Y1 - 2011/8
N2 - Innate immune receptors such as the nucleotide-binding domain, leucine-rich repeat-containing (NBD-LRR) receptors, referred to as NLRs, are known to serve as a critical component of host defense. However, their participation in inflammatory responses within immune privileged sites such as the brain and eye is less understood. The potential importance of NLRs in regulation of inflammation within these particular sites is further underscored by their association with autoinflammatory disorders, wherein localized inflammation can occur within the brain or eye as neuroinflammation or uveitis, respectively. Many NLRs are expressed within the brain and eye and in this review, we discuss their roles in the inflammation of the central nervous system (CNS) and uveitis.
AB - Innate immune receptors such as the nucleotide-binding domain, leucine-rich repeat-containing (NBD-LRR) receptors, referred to as NLRs, are known to serve as a critical component of host defense. However, their participation in inflammatory responses within immune privileged sites such as the brain and eye is less understood. The potential importance of NLRs in regulation of inflammation within these particular sites is further underscored by their association with autoinflammatory disorders, wherein localized inflammation can occur within the brain or eye as neuroinflammation or uveitis, respectively. Many NLRs are expressed within the brain and eye and in this review, we discuss their roles in the inflammation of the central nervous system (CNS) and uveitis.
UR - http://www.scopus.com/inward/record.url?scp=80051671893&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051671893&partnerID=8YFLogxK
U2 - 10.1016/j.coph.2011.07.002
DO - 10.1016/j.coph.2011.07.002
M3 - Review article
C2 - 21803656
AN - SCOPUS:80051671893
SN - 1471-4892
VL - 11
SP - 423
EP - 428
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 4
ER -