Nocturnal Hypoglycemia as a Cause of Fasting Hyperglycemia (Somogyi Phenomenon)

P. Barton Duell, Deborah Rotenstein, Sigmund R. Greenberg, Karen M. Tordjman, Carolyn E. Havlin, Lucy A. Levandoski, Neil H. White, Julio V. Santiago, Philip E. Cryer

Research output: Contribution to journalLetterpeer-review


To the Editor: Tordjman and colleagues (Dec. 17 issue)1 reported a well-designed investigation of the effects of nocturnal hypoglycemia on fasting plasma glucose concentrations in patients with insulin-dependent diabetes mellitus (IDDM). Their data, as interpreted by the authors, challenge the traditional clinical logic of many physicians and suggest that the Somogyi phenomenon may rarely, if ever, cause clinically important fasting hyperglycemia in patients with IDDM. Although their conclusions are well justified, several aspects of the methods used potentially limit the applicability of these findings to every patient with IDDM. First, the patients selected for study had relatively well-controlled IDDM (mean.

Original languageEnglish (US)
Pages (from-to)1537-1538
Number of pages2
JournalNew England Journal of Medicine
Issue number23
StatePublished - Jun 9 1988
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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