Non-motor Parkinsonism

Ronald F. Pfeiffer

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Recent years have brought increased awareness of and attention to the non-motor aspects of Parkinson's disease. Non-motor features encompass a surprisingly broad clinical spectrum that includes sensory dysfunction, behavioral abnormalities, autonomic impairment, sleep disturbances, and fatigue. Some of these features, such as impaired olfaction, REM sleep behavior disorder, and constipation, may develop long before the classic motor features of Parkinson's disease make their appearance, while others emerge in concert with disease progression. The early emergence of some non-motor features presents diagnostic opportunities, while the dopa-unresponsiveness of others poses treatment challenges, especially in the advanced stages of the disease.

Original languageEnglish (US)
Pages (from-to)S211-S220
JournalParkinsonism and Related Disorders
Issue numberSUPPL. 3
StatePublished - 2007
Externally publishedYes


  • Autonomic dysfunction
  • Behavioral abnormalities
  • Fatigue
  • Parkinson's disease
  • Sensory dysfunction
  • Sleep disturbances

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology


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